{"id":"W2035376266","doi":"10.1371/journal.ppat.1003518","title":"The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Plant-Microbe Interactions and Immunity","field":"Agricultural and Biological Sciences","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alexander von Humboldt-Stiftung; University of British Columbia; National Institutes of Health; Michael Smith Health Research BC; Nationwide Children's Hospital","keywords":"Effector; Ubiquitin ligase; Biology; Chaperone (clinical); Cell biology; Ubiquitin; Innate immune system; F-box protein; NOD1; Cullin; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003003089,0.0001669871,0.0002105754,0.00000971783,0.0006782973,0.00009800103,0.0005620107,0.00007569229,0.0008242649],"category_scores_gemma":[0.0001896982,0.00004941503,0.0001119666,0.0002791886,0.0001125187,0.0001216316,0.0001574278,0.0002953339,0.0007666833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003290324,"about_ca_system_score_gemma":0.00001048667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399402,"about_ca_topic_score_gemma":0.0005552328,"domain_scores_codex":[0.9987631,0.0003002794,0.0002255755,0.0001897808,0.0002058624,0.0003153624],"domain_scores_gemma":[0.9982625,0.001098587,0.0001139214,0.0002363441,0.000190367,0.00009828649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009244422,0.0002077369,0.0008886319,0.000002995269,0.00002700177,0.000001073575,0.0001217085,0.000001027375,0.98278,0.00001993439,0.001841263,0.01401617],"study_design_scores_gemma":[0.0001425149,0.0006411668,0.573944,0.0000357788,0.00003144959,0.00001530534,0.0008211036,0.00008200111,0.4010754,0.000058258,0.02288618,0.0002668076],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965113,0.00007269636,0.000002279954,0.001144573,0.0001798068,0.0005119838,0.0001216647,0.0000400322,0.001415711],"genre_scores_gemma":[0.9989296,0.0001355851,0.00002173877,0.000131504,0.0001163997,0.00003965397,0.00002858259,0.00000219672,0.0005947289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5817046,"threshold_uncertainty_score":0.9854417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03131843970968615,"score_gpt":0.229185099935391,"score_spread":0.1978666602257048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}