{"id":"W2035386385","doi":"10.1158/1535-7163.mct-05-0128","title":"Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Temozolomide; Poly ADP ribose polymerase; Glioma; DNA repair; Pharmacology; O-6-methylguanine-DNA methyltransferase; Cancer research; PARP inhibitor; Growth inhibition; Medicine; Chemistry; Polymerase; DNA; Methyltransferase; Cell growth; Biochemistry; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004199092,0.0005253796,0.0006621109,0.0004667103,0.000187403,0.00006777253,0.0001900911,0.0002979311,0.0003284],"category_scores_gemma":[0.00001922104,0.0005284621,0.000390049,0.001150422,0.0002987979,0.0001672897,0.00005671057,0.0004646684,0.00006240904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001211639,"about_ca_system_score_gemma":0.0004624778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002427244,"about_ca_topic_score_gemma":0.0004926684,"domain_scores_codex":[0.9962441,0.0002156997,0.0009088927,0.0008930043,0.0008702294,0.0008680292],"domain_scores_gemma":[0.9982079,0.00005625988,0.0002998238,0.001008008,0.0001879252,0.0002400591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001810455,0.0007319838,0.002122229,0.0002275534,0.000357555,0.0008847129,0.001951916,0.0001073552,0.9797226,0.001058859,0.002679011,0.008345731],"study_design_scores_gemma":[0.005375084,0.0002257843,0.001534437,0.001086765,0.00023056,0.0001332805,0.0002576039,0.0002809877,0.8047727,0.0004100375,0.1850337,0.0006590856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9050052,0.06859414,0.001441898,0.02044253,0.0004434666,0.00113283,0.0001294312,0.0004267259,0.002383735],"genre_scores_gemma":[0.9725727,0.001419327,0.004645849,0.01913498,0.0004968033,0.0003727447,0.00006128602,0.0001522153,0.00114414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1823547,"threshold_uncertainty_score":0.9997167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422417574187588,"score_gpt":0.3031121217187833,"score_spread":0.2788879459769075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}