{"id":"W2035386401","doi":"10.1016/j.jclinepi.2006.09.001","title":"A randomized trial of Pegaptanib sodium for age-related macular degeneration used an innovative design to explore disease-modifying effects","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Epidemiology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Randomized controlled trial; Randomization; Clinical trial; Macular degeneration; Confidence interval; Disease; Pegaptanib; Blinding; Internal medicine; Physical therapy; Ophthalmology; Chemotherapy; Bevacizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.006025434,0.002872382,0.007444246,0.0008489552,0.000704514,0.001346768,0.000999583,0.004135376,0.004851926],"category_scores_gemma":[0.007354643,0.001229805,0.004873167,0.0007766348,0.001863413,0.001693117,0.0008754206,0.003535371,0.0007125533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132399,"about_ca_system_score_gemma":0.001337034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021984,"about_ca_topic_score_gemma":0.001420673,"domain_scores_codex":[0.9939396,0.004123139,0.0004330796,0.0007609966,0.0002706615,0.0004725701],"domain_scores_gemma":[0.9955322,0.002639913,0.0005836615,0.0005209696,0.0002523241,0.0004710271],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9907085,0.001979268,0.0004284235,0.0001912492,0.001989442,0.00002555104,0.00001987882,0.0002192876,0.0008261774,0.0001254475,0.0001292612,0.003357661],"study_design_scores_gemma":[0.9737306,0.02349639,0.0005470507,0.000008362619,0.001338566,0.00001262848,0.000007264107,0.0003383316,0.0002181788,0.0001441938,0.000145255,0.00001305501],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773421,0.004258573,0.004270731,0.001561087,0.002456722,0.007469335,0.0008435633,0.0001717346,0.001626249],"genre_scores_gemma":[0.9800025,0.000984703,0.005844608,0.00155138,0.0009171432,0.008092245,0.0004469253,0.0000344107,0.002125951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9939746,"threshold_uncertainty_score":0.03186589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3646101121270026,"score_gpt":0.5198044841091602,"score_spread":0.1551943719821576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}