{"id":"W2035408931","doi":"10.1002/mc.20005","title":"Relationship between the radiosensitizing effect of wortmannin, DNA double‐strand break rejoining, and <i>p21<sup>WAF1</sup></i> induction in human normal and tumor‐derived cells","year":2004,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Radiosensitizer; Wortmannin; A549 cell; Cell culture; Cell cycle; Cancer research; Ionizing radiation; Radiosensitivity; Cell biology; Molecular biology; Cell; Signal transduction; Radiation therapy; Genetics; Irradiation; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005902639,0.0002779905,0.0003270512,0.0001274661,0.0001717345,0.00003615974,0.0001382632,0.0002065852,0.000001127415],"category_scores_gemma":[0.0000454742,0.000248959,0.0001150041,0.0002022757,0.0001783461,0.00001366194,0.0001355744,0.0001732113,7.281311e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003022981,"about_ca_system_score_gemma":0.00004394483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001861063,"about_ca_topic_score_gemma":0.00002764885,"domain_scores_codex":[0.9983636,0.0002527379,0.0003655809,0.0004972963,0.0002096108,0.0003111368],"domain_scores_gemma":[0.99923,0.00004485797,0.0001453406,0.0004262294,0.00005014674,0.0001034824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009939899,0.00001367097,0.08412752,0.00006986173,0.00004428265,0.00004111414,0.0002295893,0.0006846165,0.9144449,0.00004840503,0.000006484932,0.0001901298],"study_design_scores_gemma":[0.002113968,0.0003185824,0.104107,0.00004312669,0.0001282071,0.00009699932,0.00008464272,0.00001180829,0.8927842,0.00006468393,0.00002138358,0.0002254031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977397,0.001137073,0.0003871788,0.00006925574,0.00003455334,0.0004743347,0.00001150293,0.00001841144,0.0001279712],"genre_scores_gemma":[0.999324,0.00001803886,0.0003552922,0.00006984085,0.00007790158,0.00002971414,0.00006346533,0.00004691968,0.00001482217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02166075,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111430344991017,"score_gpt":0.2291659961929011,"score_spread":0.2180229616937994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}