{"id":"W2035409103","doi":"10.1038/nature11323","title":"IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":507,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Haematopoiesis; Epigenetics; Mutation; Cancer research; Progenitor cell; Epigenesis; Biology; Cell biology; Genetics; Stem cell; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788701,0.0001457055,0.0001074783,0.00004584613,0.00007869559,0.00002366411,0.00007780206,0.0006635831,0.0000117528],"category_scores_gemma":[0.0001415095,0.0001355652,0.00004629158,0.00007951843,0.00005332655,0.000006585237,0.00006747858,0.0002925992,0.000005992542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009581984,"about_ca_system_score_gemma":0.00002421362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000113321,"about_ca_topic_score_gemma":0.00001009529,"domain_scores_codex":[0.9991875,0.0000576881,0.0001517184,0.000214002,0.0001479318,0.0002411445],"domain_scores_gemma":[0.9994853,0.00001707002,0.00007183321,0.0002057304,0.00007840797,0.0001416355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006791917,0.0002019134,0.1506258,0.0001006782,0.00008979239,0.000005674489,0.0002237604,0.00005778916,0.8339676,0.0004001417,0.0008880502,0.01337088],"study_design_scores_gemma":[0.0004707603,0.0001826922,0.06471169,0.00001670788,0.0000554002,0.00003315675,0.00008359663,0.00005108076,0.9051601,0.0003374703,0.028603,0.0002943529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715019,0.02722048,0.0003766526,0.0001264521,0.0002553139,0.0001866338,0.00001327542,0.0000142965,0.0003050101],"genre_scores_gemma":[0.9962246,0.0007588275,0.001926042,0.0002071895,0.0005592174,0.00001564624,0.0001771038,0.00002512015,0.0001062128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08591412,"threshold_uncertainty_score":0.5528187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006236191513901266,"score_gpt":0.2638748249288121,"score_spread":0.2576386334149109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}