{"id":"W2035422548","doi":"10.1371/journal.pone.0044267","title":"Suppression of IFN-Induced Transcription Underlies IFN Defects Generated by Activated Ras/MEK in Human Cancer Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Biology; HT1080; Interferon; Cancer cell; Oncolytic virus; Molecular biology; Cell culture; Cancer research; Cell biology; Virology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007405696,0.0002234735,0.0002104364,0.0002369497,0.0001294001,0.0002767897,0.00009476215,0.0001608294,0.0008862076],"category_scores_gemma":[0.0001073576,0.0001366041,0.000289485,0.0002055444,0.0001665808,0.00008610922,0.0001261373,0.0002900231,0.0003656684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930025,"about_ca_system_score_gemma":0.0001856266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001224607,"about_ca_topic_score_gemma":0.001377483,"domain_scores_codex":[0.9998721,0.00001352679,0.00001291029,0.00003275661,0.00003887741,0.00002989885],"domain_scores_gemma":[0.9999201,0.00001430885,0.0000258626,0.00001388603,0.00001104927,0.00001468854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008016537,0.000006781823,0.0003742847,0.00001205963,0.000002689541,0.00003213477,0.0000137132,0.00003349355,0.9990293,0.00002366283,0.00001067053,0.0003809962],"study_design_scores_gemma":[0.000004614647,0.0001195911,0.009452929,0.000003085937,0.000009094916,0.0002603909,0.00003778924,0.0006923209,0.9883278,0.00003446003,0.001054692,0.000003295776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967448,0.0005251856,0.00142486,0.00003069693,0.000008337151,0.00001343424,0.0007730116,0.00005158143,0.000428284],"genre_scores_gemma":[0.9957386,0.0003553781,0.00167253,0.00002403655,0.00000337211,0.00001814817,0.001236571,0.00001181707,0.0009394716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224607,"threshold_uncertainty_score":0.002964616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05138250054113276,"score_gpt":0.2622117891401883,"score_spread":0.2108292885990556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}