{"id":"W2035457220","doi":"10.1074/jbc.m109.070953","title":"Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary; Structural Genomics Consortium; Simon Fraser University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Wellcome Trust; Heart and Stroke Foundation of British Columbia and Yukon; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Institute of Mental Health; Heart and Stroke Foundation of Canada; Michael Smith Health Research BC","keywords":"Bardet–Biedl syndrome; Wnt signaling pathway; Small GTPase; Cell biology; Cilium; Ciliopathy; Biology; Medicine; Signal transduction; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387109,0.0002083488,0.000253313,0.00001127283,0.0002928415,0.00006618802,0.0002645233,0.0003505988,0.0003050296],"category_scores_gemma":[0.0008150421,0.0001152715,0.0002011288,0.00007074288,0.0003817226,0.000003484231,0.0001832494,0.0003581269,0.000005418114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001611896,"about_ca_system_score_gemma":0.0001574376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004246856,"about_ca_topic_score_gemma":0.000005507376,"domain_scores_codex":[0.9988863,0.00005991644,0.0003854727,0.0002593361,0.0001337979,0.0002751264],"domain_scores_gemma":[0.9989686,0.00008041482,0.0002725048,0.0002162132,0.0001584896,0.0003037799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002666123,0.0001121395,0.006342647,0.00001727935,0.0001263254,0.00006286495,0.000013401,0.00005419194,0.9920974,3.465569e-7,0.0007761477,0.000130649],"study_design_scores_gemma":[0.001440086,0.0007620642,0.03335822,0.00005341614,0.0001783693,0.001995542,0.000232095,0.0001123361,0.9500286,0.0002021811,0.01121099,0.0004261087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998203,0.0009561891,0.00003462005,0.0003991117,0.0001418526,0.00007731611,0.00005311288,0.000009913082,0.0001248678],"genre_scores_gemma":[0.9980055,0.0002093619,0.0002890111,0.0002907906,0.0002598519,0.000005947589,0.00006032803,0.00001351522,0.0008656831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0420688,"threshold_uncertainty_score":0.4700634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014600189204951,"score_gpt":0.2187811807693165,"score_spread":0.2041809915643654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}