{"id":"W2035457220","doi":"10.1074/jbc.m109.070953","title":"Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary; Structural Genomics Consortium; Simon Fraser University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Wellcome Trust; Heart and Stroke Foundation of British Columbia and Yukon; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; National Institute of Mental Health; Heart and Stroke Foundation of Canada; Michael Smith Health Research BC","keywords":"Bardet–Biedl syndrome; Wnt signaling pathway; Small GTPase; Cell biology; Cilium; Ciliopathy; Biology; Medicine; Signal transduction; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000676488,0.0002741152,0.0001662853,0.0002000926,0.0002137695,0.0001802939,0.0001544342,0.0003649599,0.0007339848],"category_scores_gemma":[0.0000873247,0.000100758,0.0001698074,0.0001385535,0.0003012157,0.0001178384,0.0002447018,0.0002970347,0.0003043755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786442,"about_ca_system_score_gemma":0.000134268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005168265,"about_ca_topic_score_gemma":0.001215722,"domain_scores_codex":[0.9999437,0.000008662868,0.000004867504,0.00001119189,0.0000227988,0.000008715031],"domain_scores_gemma":[0.9999588,0.000005925245,0.00001432435,0.000003558476,0.000003248649,0.0000142431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009208961,0.000007026367,0.001031002,0.00002938338,0.000003348106,0.0003992389,0.00001455532,0.00017773,0.9962707,0.0003247146,0.00007155011,0.001578744],"study_design_scores_gemma":[0.00003508321,0.0001046271,0.01659926,0.000007532311,0.00001372205,0.00375575,0.00003881225,0.003598543,0.9696787,0.00030709,0.005849693,0.00001106345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953034,0.001105368,0.00219773,0.0002015221,0.00001972566,0.000006950234,0.0003415169,0.0001012702,0.0007226202],"genre_scores_gemma":[0.996157,0.0004128099,0.002622491,0.00002758861,0.00000529317,0.000004190646,0.0002192388,0.000008402056,0.0005428747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007339848,"threshold_uncertainty_score":0.002455354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014600189204951,"score_gpt":0.2187811807693165,"score_spread":0.2041809915643654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}