{"id":"W2035526755","doi":"10.1016/j.chembiol.2010.09.016","title":"Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase","year":2010,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Oxygenase; Oxidoreductase; Dimethylamine; Stereochemistry; Demethylation; Active site; Subfamily; Hydroxylation; Biosynthesis; Chemistry; Biochemistry; Biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183389,0.0002078472,0.0002061895,0.00001505041,0.0000922693,0.00001078529,0.0001689628,0.0002273011,0.0000855705],"category_scores_gemma":[0.0003234893,0.0001726503,0.00005088924,0.00003809068,0.0003226794,0.000001197225,0.0001385672,0.0001603077,0.000009027047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001496734,"about_ca_system_score_gemma":0.00003086119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002977197,"about_ca_topic_score_gemma":0.00001113402,"domain_scores_codex":[0.9990414,0.00002254055,0.000179364,0.0004553198,0.00004820747,0.0002531651],"domain_scores_gemma":[0.9993778,0.00002065489,0.00007122492,0.000369709,0.00005603771,0.0001045136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003986467,0.00001402035,0.0005802544,0.00003095355,0.00005521123,0.000001798656,0.00002252761,0.000004131843,0.9960942,0.0008610126,0.0002914802,0.00200449],"study_design_scores_gemma":[0.0006199366,0.0001310871,0.000447084,0.000005093515,0.00003130043,0.00004448319,0.0001201984,0.0000565194,0.9736995,0.003417608,0.02115076,0.0002764633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959279,0.002006372,0.00002647294,0.0001594889,0.0004249523,0.00007993772,0.00003443734,0.00001557258,0.001324853],"genre_scores_gemma":[0.997633,0.000321641,0.0002990593,0.0003094029,0.0004042611,0.00001769567,0.0001622813,0.00001593072,0.0008367716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02239479,"threshold_uncertainty_score":0.7040474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009443332344043607,"score_gpt":0.2740596248551634,"score_spread":0.2646162925111198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}