{"id":"W2035526755","doi":"10.1016/j.chembiol.2010.09.016","title":"Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase","year":2010,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Oxygenase; Oxidoreductase; Dimethylamine; Stereochemistry; Demethylation; Active site; Subfamily; Hydroxylation; Biosynthesis; Chemistry; Biochemistry; Biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372669,0.0004319662,0.0001940351,0.0001083446,0.0002414054,0.0002491691,0.0004606564,0.0003016234,0.001173778],"category_scores_gemma":[0.0002570687,0.0001045258,0.0001945141,0.0001570999,0.0003914206,0.0004930821,0.000179485,0.0009839212,0.0002095855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004908403,"about_ca_system_score_gemma":0.0003459299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00173503,"about_ca_topic_score_gemma":0.001021764,"domain_scores_codex":[0.999948,0.000006896034,0.000003002601,0.00001067394,0.00001430224,0.00001716895],"domain_scores_gemma":[0.9998986,0.00003111384,0.0000212835,0.00001031902,0.00001551922,0.00002322651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006760383,0.0001649711,0.0008434393,0.0002023418,0.00002803592,0.0008250175,0.0001261047,0.003675504,0.9735923,0.009720029,0.0004163436,0.009729739],"study_design_scores_gemma":[0.00004456613,0.000365616,0.002094617,0.0000102881,0.00002989647,0.0006541564,0.0001772171,0.003620322,0.9808109,0.002429079,0.009746084,0.00001716956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837479,0.00345033,0.005700991,0.001374078,0.00009943722,0.00002565209,0.0002572926,0.00005277003,0.005291654],"genre_scores_gemma":[0.9924431,0.003415941,0.001930706,0.0001035588,0.00002512632,0.000006965771,0.0004430499,0.000006920269,0.001624629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173503,"threshold_uncertainty_score":0.003926635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009443332344043607,"score_gpt":0.2740596248551634,"score_spread":0.2646162925111198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}