{"id":"W2035571342","doi":"10.1007/s11033-011-0744-z","title":"The 156KELK159 tetrapeptide of HIV-1 integrase is critical for lentiviral gene integration","year":2011,"lang":"en","type":"article","venue":"Molecular Biology Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; California Institute of Technology","keywords":"Integrase; Biology; Reporter gene; Lentivirus; Virology; Molecular biology; Gene; Viral vector; Tetrapeptide; Gene expression; Virus; Genetics; Recombinant DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275424,0.0004012737,0.000512687,0.0001939692,0.0003174023,0.0006627268,0.0003922057,0.0009647461,0.003642725],"category_scores_gemma":[0.0004688228,0.0002819524,0.0003704609,0.00009364217,0.0004544274,0.0005913634,0.000491667,0.0009574631,0.002359787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005374106,"about_ca_system_score_gemma":0.0003902315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693214,"about_ca_topic_score_gemma":0.0001947386,"domain_scores_codex":[0.99972,0.00003593398,0.00005066614,0.00006177908,0.00008869392,0.0000428803],"domain_scores_gemma":[0.9995818,0.00007163164,0.0001323868,0.0000425917,0.00003625347,0.0001354285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000188793,0.00002058139,0.0001848228,0.00004717898,0.000007915311,0.0003592179,0.00001051846,0.0001723627,0.9968646,0.0003071882,0.00004104426,0.001795617],"study_design_scores_gemma":[0.00003343284,0.0001111049,0.001688612,0.00001225835,0.00001105095,0.001308011,0.00001576726,0.0005822786,0.993957,0.0001939518,0.002077594,0.000008912936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890115,0.00101881,0.005747883,0.0002486132,0.0001222587,0.00004723403,0.000312903,0.0002040733,0.003286634],"genre_scores_gemma":[0.9920238,0.0002477614,0.004885266,0.000198926,0.00002254068,0.00002510588,0.000483426,0.00007138181,0.00204173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003642725,"threshold_uncertainty_score":0.01218617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260931738818369,"score_gpt":0.3318532813177489,"score_spread":0.305760107435912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}