{"id":"W2035615837","doi":"10.1016/j.bbabio.2010.12.002","title":"AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation","year":2010,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Agence Nationale de la Recherche; Cancéropôle Grand Ouest; Institut National de la Santé et de la Recherche Médicale; Institut national de la recherche scientifique","keywords":"Biogenesis; Oxidative stress; Cell biology; Protein kinase B; Oxidative phosphorylation; Cell growth; PI3K/AKT/mTOR pathway; Cell; Chemistry; Cancer research; Biology; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790454,0.0006869196,0.0006796265,0.0006424568,0.0004104915,0.0005340241,0.0003535177,0.0005689879,0.003038953],"category_scores_gemma":[0.0002444217,0.00030977,0.0005211055,0.0005066495,0.0005756774,0.0002522921,0.0003957505,0.001372723,0.000655991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000569143,"about_ca_system_score_gemma":0.0005750451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321363,"about_ca_topic_score_gemma":0.005398575,"domain_scores_codex":[0.9996498,0.00007164983,0.00004203457,0.00003747592,0.00006089553,0.0001381272],"domain_scores_gemma":[0.9997668,0.00006532469,0.00003792009,0.00005293793,0.00001643133,0.00006065828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005454671,0.00036263,0.0006908824,0.0001378548,0.00006606093,0.0003308093,0.00006085545,0.0002776536,0.9863913,0.0003789382,0.0008325239,0.005015847],"study_design_scores_gemma":[0.0003081554,0.001750332,0.01342641,0.00001613532,0.00007486085,0.0005704911,0.0001115754,0.0007422581,0.9781004,0.0001705518,0.00470798,0.00002079257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847441,0.006375092,0.001203426,0.0007338274,0.0002920434,0.00004896245,0.002187074,0.0003768913,0.004038613],"genre_scores_gemma":[0.9925262,0.002312048,0.0008081605,0.0001605329,0.00005824635,0.00006684215,0.001498553,0.0000344959,0.002534916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003038953,"threshold_uncertainty_score":0.01016629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005702060749352376,"score_gpt":0.2304022298626323,"score_spread":0.22470016911328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}