{"id":"W2035625775","doi":"10.1002/jcp.22519","title":"Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Health Canada; National Institutes of Health","keywords":"Myocardin; Degradation (telecommunications); Vascular smooth muscle; Cell biology; Smooth muscle; Chemistry; Biology; Biochemistry; Endocrinology; Transcription factor; Gene; Serum response factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005294692,0.0001415682,0.000317983,0.00009202987,0.00003633727,0.000006359999,0.0002120604,0.0002538319,0.00004328982],"category_scores_gemma":[0.00007353027,0.0001296462,0.0003390849,0.00007589329,0.00007659326,0.00001645068,0.00002693759,0.0002367165,0.000001753469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001064971,"about_ca_system_score_gemma":0.0001541778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004905833,"about_ca_topic_score_gemma":0.000006134612,"domain_scores_codex":[0.9989083,0.0001351196,0.0003824676,0.0002065824,0.0001562056,0.0002113257],"domain_scores_gemma":[0.9990973,0.00002431103,0.0003663422,0.000198919,0.0002450665,0.00006800483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003727096,0.000190179,0.00003795921,0.00007388469,0.00005532149,0.000001504824,0.00006249537,0.00004396862,0.9971088,0.0001330989,0.000102756,0.001817286],"study_design_scores_gemma":[0.001361892,0.000634716,0.006371772,0.00001720806,0.00002695938,0.00000314496,0.00001819798,0.0001691467,0.9792247,0.0004264739,0.01161934,0.0001263791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994583,0.0003275653,0.0041535,0.0001034724,0.0003531214,0.0003653895,0.00004492813,0.000002222831,0.00006683913],"genre_scores_gemma":[0.997588,0.00006497293,0.001774346,0.0000614708,0.000388159,0.00002225229,0.0000285951,0.00001850986,0.00005372048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01788407,"threshold_uncertainty_score":0.528682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697569515517131,"score_gpt":0.2426410181236506,"score_spread":0.2256653229684793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}