{"id":"W2035631829","doi":"10.1242/jcs.03185","title":"HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage","year":2006,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Western University","funders":"","keywords":"Mef2; Biology; MEF2C; GATA4; Histone deacetylase 5; Cell biology; Myogenic regulatory factors; HDAC4; P19 cell; Downregulation and upregulation; Myocyte; Trichostatin A; Cellular differentiation; Wortmannin; Molecular biology; Histone deacetylase; Gene expression; Histone; Signal transduction; Enhancer; MyoD; Genetics; Adult stem cell; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001286839,0.00008150994,0.0001440719,0.00007562272,0.0001429978,0.00003196885,0.0005232747,0.00006065694,0.000009548658],"category_scores_gemma":[0.00008317672,0.00005595175,0.0001432902,0.0002787764,0.000648125,0.00001583524,0.0001392919,0.0001648467,0.000003354827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004300401,"about_ca_system_score_gemma":0.0003605465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008530364,"about_ca_topic_score_gemma":0.0000144344,"domain_scores_codex":[0.9986987,0.00008598725,0.0002509384,0.0001623479,0.0005794938,0.0002225351],"domain_scores_gemma":[0.9989962,0.00003771236,0.0002682061,0.0002950497,0.0003195903,0.00008326445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002361857,0.00007164107,0.0001106251,0.000009717442,0.000003970899,0.00000344016,0.0001001865,0.0002173199,0.9955217,0.000004485056,0.002970365,0.0009629746],"study_design_scores_gemma":[0.0001455473,0.0001455071,0.002382548,0.00001039699,0.000007459814,0.000005191528,0.00004988937,0.00007499413,0.9834255,0.00001779573,0.01367363,0.00006154058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962569,0.00076102,0.0001402116,0.0001586328,0.0002434955,0.00006623699,0.000002634562,0.000001362832,0.002369493],"genre_scores_gemma":[0.99776,0.0001476736,0.0005944758,0.00001516442,0.0003197384,7.695376e-7,5.73712e-7,0.000006703576,0.00115489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209616,"threshold_uncertainty_score":0.2388043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004256814970401758,"score_gpt":0.2450346195263599,"score_spread":0.2407778045559582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}