{"id":"W2035678900","doi":"10.1016/j.memsci.2011.11.049","title":"Simultaneous removal of leached protein-A and aggregates from monoclonal antibody using hydrophobic interaction membrane chromatography","year":2011,"lang":"en","type":"article","venue":"Journal of Membrane Science","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hydrophilic interaction chromatography; Chemistry; Monoclonal antibody; Membrane; Chromatography; Hydrophobic effect; Antibody; Biochemistry; High-performance liquid chromatography; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006864895,0.0001143547,0.0002024418,0.0001433742,0.0000938948,0.00002416558,0.0003073154,0.00007099678,0.00003016824],"category_scores_gemma":[0.0003085909,0.00009501797,0.00009101387,0.0002480745,0.0005514973,0.00004039397,0.00006362733,0.0001289611,5.418913e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001545679,"about_ca_system_score_gemma":0.000178744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009590663,"about_ca_topic_score_gemma":0.000003993731,"domain_scores_codex":[0.9987921,0.0000717527,0.0004255729,0.0002471152,0.0003062615,0.0001572122],"domain_scores_gemma":[0.9987884,0.00002208397,0.0005276905,0.000233957,0.0003090333,0.0001188489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002589479,0.00009529539,0.0005663827,0.00002214085,0.0000230292,0.00002123326,0.0001951876,0.00005881505,0.9970561,0.00001420133,2.50805e-7,0.001688404],"study_design_scores_gemma":[0.0004086705,0.0002621149,0.001890826,0.00006669705,0.00002004979,0.0004728502,0.0001379934,0.00216943,0.9941464,0.0001268454,0.0001937518,0.0001043658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973949,0.001384117,0.0007321829,0.00002971202,0.0001257024,0.0001412327,0.000006455226,0.000003537938,0.0001822069],"genre_scores_gemma":[0.9885364,0.0001772845,0.01118911,0.0000168457,0.00005917719,8.056831e-7,0.000002660894,0.000006913907,0.00001080078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01045693,"threshold_uncertainty_score":0.3874721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239180491914724,"score_gpt":0.2825962144886822,"score_spread":0.2602044095695349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}