{"id":"W2035692565","doi":"10.1016/j.cmet.2008.01.008","title":"ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress","year":2008,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Unfolded protein response; Endoplasmic reticulum; ATF4; Pancreatic islets; Cell biology; Biology; Apoptosis; Programmed cell death; Transcription factor; Endocrinology; Internal medicine; Cancer research; Diabetes mellitus; Islet; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002539825,0.0007194089,0.0005768457,0.0005282225,0.0004471159,0.0005379023,0.0003416764,0.0003641133,0.003360533],"category_scores_gemma":[0.0001867245,0.0003114776,0.000708757,0.0003380516,0.0003961331,0.0005457774,0.0004718222,0.001124162,0.0009621177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006902652,"about_ca_system_score_gemma":0.0003595493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008380185,"about_ca_topic_score_gemma":0.0008631566,"domain_scores_codex":[0.9998357,0.00002340105,0.00001272968,0.00003342495,0.00003208152,0.00006257198],"domain_scores_gemma":[0.9998349,0.00001566953,0.00003791396,0.00002334312,0.0000383896,0.00004978337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007469281,0.00006037927,0.0002888833,0.00006511686,0.00001430548,0.0001118254,0.00001522181,0.00005900286,0.9960121,0.0001576478,0.0001603633,0.002308196],"study_design_scores_gemma":[0.00004520491,0.0001573555,0.01280817,0.000009603344,0.00003007964,0.0004295082,0.00008496161,0.0007546459,0.9824134,0.0002823429,0.002974933,0.000009762952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829775,0.004806393,0.005779877,0.0009921899,0.0002976825,0.00004033492,0.001323561,0.000267135,0.003515363],"genre_scores_gemma":[0.9803498,0.002299828,0.0051969,0.0002665092,0.00008942834,0.00005622694,0.003074834,0.00009274224,0.0085738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003360533,"threshold_uncertainty_score":0.01124215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777527532503547,"score_gpt":0.226187803341806,"score_spread":0.2084125280167705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}