{"id":"W2035694281","doi":"10.1074/jbc.m702988200","title":"Functional Silencing of TATA-binding Protein (TBP) by a Covalent Linkage of the N-terminal Domain of TBP-associated Factor 1","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"TATA-binding protein; Linker; TATA-Box Binding Protein; Transcription factor II A; Chemistry; Fusion protein; Biophysics; Crystallography; Transcription factor; Biology; Biochemistry; DNA-binding protein; Promoter; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656904,0.0003684644,0.000201143,0.00008964556,0.0001688848,0.0002389539,0.0002626264,0.000228295,0.0007490752],"category_scores_gemma":[0.0001223829,0.000128461,0.0002596304,0.00009592122,0.0003048044,0.0001471131,0.0003093341,0.0004609799,0.0002646879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666662,"about_ca_system_score_gemma":0.0001901138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004616904,"about_ca_topic_score_gemma":0.0007849019,"domain_scores_codex":[0.9998944,0.00001702363,0.00001148673,0.0000304168,0.00002717342,0.00001959374],"domain_scores_gemma":[0.9999094,0.00001710206,0.0000355507,0.000011473,0.000008249668,0.0000183074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001750182,0.00000584869,0.00002884606,0.00001194946,0.000001806086,0.000009721242,0.000005265591,0.0000495251,0.9994621,0.00004549171,0.000008416934,0.0003535287],"study_design_scores_gemma":[0.000006111353,0.00007007887,0.0006798342,0.000002200438,0.000008529069,0.00009657676,0.000007879724,0.0009946277,0.9966764,0.00001749906,0.001437552,0.00000270964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908175,0.0005782722,0.007502013,0.00006185882,0.00002602714,0.00002857546,0.0002345988,0.0001190661,0.0006320115],"genre_scores_gemma":[0.991298,0.0004395408,0.005786346,0.00003759644,0.000008480955,0.00003547034,0.0004316004,0.00003553637,0.001927417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007490752,"threshold_uncertainty_score":0.002505898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0246886634452432,"score_gpt":0.2696144757715335,"score_spread":0.2449258123262903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}