{"id":"W2035712312","doi":"10.1016/j.ijrobp.2008.05.068","title":"Motexafin Gadolinium Combined With Prompt Whole Brain Radiotherapy Prolongs Time to Neurologic Progression in Non–Small-Cell Lung Cancer Patients With Brain Metastases: Results of a Phase III Trial","year":2008,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec; Juravinski Cancer Centre; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Hazard ratio; Radiosurgery; Lung cancer; Neurocognitive; Clinical endpoint; Adverse effect; Randomized controlled trial; Radiation therapy; Confidence interval; Internal medicine; Cancer; Brain metastasis; Oncology; Surgery; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008544897,0.001692787,0.002785773,0.0003470841,0.0003859282,0.0008937253,0.0009545139,0.001153578,0.002063516],"category_scores_gemma":[0.0009116955,0.0004665694,0.001497876,0.0004768405,0.001091826,0.0008580519,0.0002984537,0.003421088,0.0005054544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009100457,"about_ca_system_score_gemma":0.001134876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002142613,"about_ca_topic_score_gemma":0.004203334,"domain_scores_codex":[0.9997125,0.000115156,0.00001377363,0.00005182044,0.00002050882,0.00008614198],"domain_scores_gemma":[0.9994534,0.0001389501,0.0001240744,0.00004229627,0.0000218033,0.0002196013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8900169,0.01901211,0.003725477,0.0007172457,0.002048854,0.0001667758,0.0001750389,0.001962542,0.01281483,0.0002244267,0.002631872,0.06650393],"study_design_scores_gemma":[0.6156283,0.365882,0.01287666,0.00004845189,0.0009051647,0.0002451776,0.00006992205,0.001059907,0.001940909,0.0002247508,0.001079369,0.00003930517],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964347,0.001947531,0.0001529942,0.0002936408,0.0001285004,0.0002402883,0.0002181854,0.00004994692,0.0005341697],"genre_scores_gemma":[0.9949911,0.002088207,0.0003926388,0.0003395884,0.0001608718,0.0004117277,0.0005320166,0.00002163639,0.001062203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002785773,"threshold_uncertainty_score":0.006903112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492876678207276,"score_gpt":0.3300046206088674,"score_spread":0.3150758538267946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}