{"id":"W2035728929","doi":"10.1016/j.ajhg.2011.07.025","title":"Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection","year":2011,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health; Wellcome Trust; National Heart, Lung, and Blood Institute; Foundation for the National Institutes of Health","keywords":"Natural selection; Biology; Population; Evolutionary biology; Selection (genetic algorithm); Allele; Allele frequency; Genetics; Negative selection; Genome; Gene; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082282,0.000368632,0.0005610243,0.001490819,0.001318666,0.0009908774,0.00069825,0.0006300242,0.003203599],"category_scores_gemma":[0.003558334,0.0002236653,0.0006198274,0.001659935,0.0007686115,0.0003225527,0.0008404937,0.0006379131,0.0001637838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674331,"about_ca_system_score_gemma":0.0003965102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01288776,"about_ca_topic_score_gemma":0.01380456,"domain_scores_codex":[0.9987003,0.0005072509,0.00006966262,0.0003805908,0.0001303804,0.0002118216],"domain_scores_gemma":[0.9984185,0.0006327722,0.0002999089,0.0002116076,0.0001498802,0.000287436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001872941,0.0001052463,0.9680856,0.0000392675,0.0008583901,0.000492317,0.002275785,0.00013987,0.01787444,0.0006548354,0.0004527209,0.0071486],"study_design_scores_gemma":[0.000029386,0.00009613436,0.9982448,0.000007565138,0.0001291902,0.0002569229,0.0004164902,0.0001495199,0.0002727291,0.0001592263,0.0002318258,0.000006256092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992595,0.0001357784,0.0001709325,0.00005187497,0.000005530518,0.000003400002,0.0001281377,0.000003834452,0.0002410194],"genre_scores_gemma":[0.9995044,0.00005800995,0.0001299276,0.00003791415,0.00000687171,0.000005219711,0.0001366199,0.000004973866,0.0001158797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01288776,"threshold_uncertainty_score":0.02562547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04439938416158516,"score_gpt":0.3214494866235367,"score_spread":0.2770501024619515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}