{"id":"W2035757354","doi":"10.1056/nejmoa032909","title":"Interferon Regulatory Factor 6 ( <i>IRF6</i> ) Gene Variants and the Risk of Isolated Cleft Lip or Palate","year":2004,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":583,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"National Institute of Dental and Craniofacial Research; Egmont Fonden; National Institute of General Medical Sciences; March of Dimes Foundation; National Institutes of Health; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Genetics; Linkage disequilibrium; Candidate gene; Allele; Haplotype; Medicine; Single-nucleotide polymorphism; Population; Gene; Genetic variation; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003481293,0.0003250811,0.0002111702,0.000575617,0.0002332401,0.0002706045,0.0002663016,0.0004330693,0.003914273],"category_scores_gemma":[0.001392273,0.0001276257,0.0002415184,0.0004442544,0.0002897089,0.0001388127,0.0001882941,0.0003212463,0.0002632358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274556,"about_ca_system_score_gemma":0.0001239439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269487,"about_ca_topic_score_gemma":0.0007792506,"domain_scores_codex":[0.9998106,0.0000483284,0.00001967901,0.0000670059,0.00002890569,0.0000254013],"domain_scores_gemma":[0.9992564,0.000307569,0.0002826797,0.00002750309,0.00003807234,0.00008769879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006107072,0.0000533482,0.9875087,0.00002437039,0.0001543547,0.0006803484,0.00007599994,0.0002125852,0.006545984,0.00006939593,0.000170654,0.003893469],"study_design_scores_gemma":[0.00006439535,0.0002262831,0.9891433,0.00002636529,0.000191619,0.006286153,0.0001058258,0.0008162338,0.00248926,0.0002120454,0.0004301492,0.000008388694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999313,0.000180634,0.0001599102,0.00002747549,0.000002773006,0.000003420054,0.0001110118,0.000004992672,0.0001968018],"genre_scores_gemma":[0.9993537,0.00008018743,0.0002743408,0.00001458452,0.000006315632,0.000004167123,0.000130996,0.000003431429,0.000132307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003914273,"threshold_uncertainty_score":0.01309454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390107942500115,"score_gpt":0.2676353972467266,"score_spread":0.2537343178217255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}