{"id":"W2035757734","doi":"10.1016/j.jconrel.2004.09.014","title":"Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery","year":2004,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"HBcAg; PLGA; Immune system; Antigen; Immunization; Adjuvant; Hepatitis B virus; Virology; Immunology; Medicine; Virus; HBsAg; Materials science; Nanoparticle; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006113542,0.0002359258,0.001312065,0.0002135719,0.0001101774,0.00001443787,0.0001422962,0.0000924693,0.0002119394],"category_scores_gemma":[0.001473257,0.0001752224,0.0003505265,0.0002646649,0.00007997506,0.0001498009,0.00004910478,0.0002822721,0.00004400357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002173828,"about_ca_system_score_gemma":0.0005102543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000784128,"about_ca_topic_score_gemma":0.0002054381,"domain_scores_codex":[0.997371,0.0001246967,0.001378161,0.0001650259,0.0006265028,0.0003345837],"domain_scores_gemma":[0.9972924,0.0002263429,0.0008545439,0.0002812492,0.001101273,0.0002441851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02674551,0.0009115542,0.02980621,0.00005039524,0.000966311,0.0005790077,0.0003530674,0.00006626931,0.9353133,0.00001997562,0.0031912,0.00199714],"study_design_scores_gemma":[0.07333523,0.006767055,0.04802721,0.00111579,0.0008372994,0.0001778425,0.0001206687,0.0002125861,0.8626432,0.0001018407,0.006314544,0.000346713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748925,0.02237386,0.0001433896,0.001486714,0.0003503313,0.000516862,0.00002481349,0.00001547471,0.0001960421],"genre_scores_gemma":[0.9712799,0.02659914,0.0004752426,0.0008745308,0.0001583588,0.00001009178,0.000004966495,0.00003077301,0.0005669753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07267013,"threshold_uncertainty_score":0.7145364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511144614522121,"score_gpt":0.2719411451385952,"score_spread":0.256829698993374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}