{"id":"W2035774055","doi":"10.1186/s12916-015-0328-1","title":"No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over","year":2015,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Frailty in Older Adults","field":"Medicine","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University; Queen Elizabeth II Health Sciences Centre","funders":"Servier; Dunhill Medical Trust; British Heart Foundation; National Institute for Health and Care Research; Imperial College London; Advantage West Midlands","keywords":"Medicine; Stroke (engine); Placebo; Indapamide; Blood pressure; Internal medicine; Population; Quality of life (healthcare); Physical therapy; Depression (economics); Perindopril; Proportional hazards model; Gerontology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003304952,0.0007765573,0.003167335,0.0006707088,0.0001016419,0.00002309197,0.0004648578,0.0002045063,0.000006594524],"category_scores_gemma":[0.002347905,0.000269942,0.0003190108,0.001602966,0.0005234907,0.0003770578,0.00008738331,0.0005131749,4.406607e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004778401,"about_ca_system_score_gemma":0.0008979603,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1392787,"about_ca_topic_score_gemma":0.07660987,"domain_scores_codex":[0.9917784,0.004007745,0.001473298,0.0007317062,0.001529764,0.0004791401],"domain_scores_gemma":[0.9899595,0.006707041,0.001083192,0.001498268,0.0006086718,0.0001432674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3074523,0.003942497,0.6052321,0.00007411736,0.0004538302,0.0001293835,0.07319205,0.0007972629,0.008245836,6.729489e-7,0.00003503289,0.0004449204],"study_design_scores_gemma":[0.2779217,0.09077435,0.5888981,0.001359943,0.0008323873,0.00010814,0.03784836,0.001626272,0.0004782009,0.000008685004,5.555215e-8,0.0001437678],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796673,0.001161732,0.00000122226,0.0005407932,0.0001294588,0.01845137,0.00001578831,0.00001173022,0.0000206258],"genre_scores_gemma":[0.9990008,0.0002132948,0.00001167892,0.0000857726,0.00009094612,0.0005164476,0.0000299768,0.00004247975,0.000008555415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08683185,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1101775865033165,"score_gpt":0.3540489560763369,"score_spread":0.2438713695730204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}