{"id":"W2035779766","doi":"10.1002/glia.20478","title":"Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia","year":2007,"lang":"en","type":"article","venue":"Glia","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Calgary","funders":"","keywords":"Microglia; Matrix metalloproteinase; Biology; Neuroinflammation; TIMP1; Tumor necrosis factor alpha; Cytokine; Immunology; Tissue inhibitor of metalloproteinase; Metalloproteinase; Downregulation and upregulation; Immune system; Inflammation; Cell biology; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003280317,0.0002454486,0.0002850143,0.0001203681,0.00004570446,0.00002692176,0.0001438989,0.0001799566,0.00001109672],"category_scores_gemma":[0.00004487992,0.0002095672,0.00003992155,0.0001594179,0.00006623392,0.00001209535,0.00009841682,0.0001498916,0.000003685822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003853756,"about_ca_system_score_gemma":0.00004686939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002768079,"about_ca_topic_score_gemma":0.001782512,"domain_scores_codex":[0.998691,0.00006036756,0.0002780276,0.0004507632,0.0001161927,0.0004036068],"domain_scores_gemma":[0.9994235,0.00001208001,0.0001236062,0.0002926315,0.00005898298,0.0000892245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005583023,0.00009159436,0.004788016,0.00002397447,0.0000349253,0.0000852848,0.00007858987,0.000008653384,0.993784,0.00003312314,0.00005056203,0.0004629701],"study_design_scores_gemma":[0.001845717,0.000204481,0.03235006,0.00008256589,0.00001190581,0.00003047597,0.0001683805,0.00001132686,0.9638551,0.0002606988,0.0008964691,0.0002827901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980401,0.001043,0.000192667,0.0000692402,0.00004088394,0.0004331627,0.00002785757,0.00001823428,0.0001347965],"genre_scores_gemma":[0.9979831,0.00003687763,0.001424547,0.000144497,0.00006723302,0.00002747881,0.00005463775,0.00002888499,0.0002327447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02992887,"threshold_uncertainty_score":0.8545904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249570720387923,"score_gpt":0.2353551283559941,"score_spread":0.2228594211521149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}