{"id":"W2035797484","doi":"10.1016/j.bpj.2013.11.3274","title":"Spermine Selectively Inhibits High-Conductance but not Low-Conductance Mode of the Mitochondrial Permeability Transition Pore (MPTP)","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"MPTP; Mitochondrial permeability transition pore; Spermine; Depolarization; Mitochondrion; Calcium; Chemistry; Polyamine; Biophysics; Inner mitochondrial membrane; Membrane potential; Biochemistry; Programmed cell death; Biology; Apoptosis; Endocrinology; Enzyme; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009130188,0.0001741164,0.0002333886,0.00002094241,0.0001625423,0.00002185159,0.000313505,0.0001158595,0.00001096473],"category_scores_gemma":[0.0000993696,0.0001247258,0.0002096138,0.0001540657,0.0002486741,0.00001471465,0.00004796929,0.0002472776,0.000004533822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001671986,"about_ca_system_score_gemma":0.00009673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002182476,"about_ca_topic_score_gemma":0.000007870948,"domain_scores_codex":[0.9987864,0.0001242051,0.0003118294,0.0003088962,0.000232016,0.0002366766],"domain_scores_gemma":[0.9991225,0.00001726458,0.0001974949,0.0003628928,0.0001945901,0.0001052567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028128,0.0001758995,0.00002496176,0.00001130507,0.00002052928,3.43847e-7,0.0000433744,0.00005407411,0.9975008,0.0009509955,0.0001842065,0.000930632],"study_design_scores_gemma":[0.000699045,0.0001001818,0.005313309,0.00001747738,0.0000339581,0.00004037691,0.00001446417,0.0002273972,0.9915574,0.001178503,0.0006644243,0.0001535067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941629,0.00002837868,0.004301935,0.0007923002,0.0003142037,0.0001684229,0.0001323287,0.00000677973,0.000092728],"genre_scores_gemma":[0.9964901,0.00002357855,0.0009524037,0.0002703891,0.002085723,0.00001255266,0.00003276336,0.00001697998,0.0001155643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005943509,"threshold_uncertainty_score":0.5086172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007249100902126865,"score_gpt":0.2355166891399188,"score_spread":0.2282675882377919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}