{"id":"W2035824694","doi":"10.1073/pnas.0911811107","title":"Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health; American Heart Association","keywords":"Virulence; Biology; Mutant; Mutation; Microbiology; Protease; Gene; Streptococcus; Fasciitis; Genetics; Single-nucleotide polymorphism; Genotype; Bacteria; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303218,0.000301409,0.0002083299,0.0002173431,0.00007642013,0.0001575713,0.00008872461,0.00018376,0.0008585144],"category_scores_gemma":[0.0002096417,0.00007500241,0.0001252892,0.00009930356,0.0002364898,0.00008581698,0.0001344116,0.0002603167,0.0001199016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818609,"about_ca_system_score_gemma":0.0000997287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001463558,"about_ca_topic_score_gemma":0.0002128545,"domain_scores_codex":[0.9998834,0.00002923611,0.00001292282,0.000031002,0.00002624675,0.00001721775],"domain_scores_gemma":[0.9998714,0.00002637815,0.00005610165,0.00001324539,0.000009135967,0.00002369807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004694486,0.00001506813,0.0008681663,0.00001034682,0.000004323223,0.0001421034,0.000004837138,0.00003465864,0.9976642,0.00005509629,0.00001355193,0.001140762],"study_design_scores_gemma":[0.00002420302,0.001114121,0.06908904,0.00001200121,0.00003767863,0.006402058,0.00006950023,0.001762514,0.9193608,0.0002521193,0.00186392,0.00001203207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978414,0.0002652415,0.001185606,0.0000637171,0.00001124754,0.000007454405,0.0001000662,0.00004383223,0.000481406],"genre_scores_gemma":[0.9986351,0.0001510365,0.0008257046,0.00002610805,0.000004915387,0.000004867875,0.0001048145,0.000006642386,0.0002408787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008585144,"threshold_uncertainty_score":0.00287205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05550394024783645,"score_gpt":0.3011748674418446,"score_spread":0.2456709271940081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}