{"id":"W2035825135","doi":"10.1080/09687860400014872","title":"Carbonic anhydrase inhibitors that directly inhibit anion transport by the human Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup>exchanger, AE1","year":2004,"lang":"en","type":"article","venue":"Molecular Membrane Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Bicarbonate; Carbonic anhydrase; Intracellular pH; DIDS; Antiporter; Organic cation transport proteins; Membrane transport; Biochemistry; Symporter; Substrate (aquarium); Ion transporter; Transporter; Intracellular; Enzyme; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570466,0.000396051,0.0003979691,0.0001203706,0.00009512338,0.0001726535,0.0002000636,0.0001926271,0.001044475],"category_scores_gemma":[0.000127546,0.0000999752,0.0002470032,0.000177409,0.00009490992,0.0001185723,0.00008965317,0.0004973334,0.0002583781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003363838,"about_ca_system_score_gemma":0.0003002446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000982804,"about_ca_topic_score_gemma":0.004553738,"domain_scores_codex":[0.9998811,0.00001467789,0.00001796023,0.00002366574,0.0000350854,0.00002748813],"domain_scores_gemma":[0.9999417,0.00001348068,0.00001588387,0.000004111945,0.00001099688,0.00001390552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008104878,0.0003819038,0.0006992291,0.0002448846,0.00006760367,0.0001189913,0.00002452738,0.0002241374,0.9798753,0.0001464022,0.0005720812,0.01683442],"study_design_scores_gemma":[0.0003724881,0.003649625,0.007383612,0.00001477323,0.0001007341,0.0004314272,0.00002391537,0.0007796009,0.9758261,0.00002831065,0.01138139,0.000008083644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643803,0.02829597,0.002321865,0.0002879895,0.000161958,0.0002472437,0.001115416,0.000113385,0.003075837],"genre_scores_gemma":[0.9710136,0.01725221,0.00509651,0.0002274982,0.00005998139,0.0002305204,0.001617904,0.0000222202,0.00447951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044475,"threshold_uncertainty_score":0.003494143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868121885284778,"score_gpt":0.2213436135362768,"score_spread":0.212662394683429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}