{"id":"W2035838135","doi":"10.1371/journal.pone.0073296","title":"The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis (RIP)","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Karolinska Institutet; McGill University","keywords":"Ectodomain; ADAM10; Cell biology; Disintegrin; Biology; Chemistry; Biochemistry; Receptor; Metalloproteinase; Matrix metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183497,0.0001388274,0.0001417972,0.00002785149,0.0002120917,0.0001311861,0.00009500979,0.0001131449,0.00009021562],"category_scores_gemma":[0.0001862625,0.0001041832,0.00003276875,0.00007855023,0.0001819215,0.00001061838,0.00008782063,0.00006821637,0.00002300503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001037885,"about_ca_system_score_gemma":0.00002749211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000041399,"about_ca_topic_score_gemma":0.00002113652,"domain_scores_codex":[0.9991008,0.00008390885,0.0001760468,0.0002831976,0.0001528919,0.0002031775],"domain_scores_gemma":[0.9993838,0.00003635428,0.00007327145,0.0002699205,0.00008164688,0.0001549712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009747493,0.0001111703,0.002817636,0.00004009046,0.0001818142,7.568337e-7,0.00002820319,0.00000289778,0.993218,0.0001402884,0.0006416606,0.002719991],"study_design_scores_gemma":[0.002015486,0.0003412328,0.0346736,0.0001182709,0.0002285513,0.00001100357,0.000329931,0.001674601,0.9556569,0.001177394,0.00319953,0.0005734975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953994,0.002504901,0.00004208503,0.001216336,0.00001815016,0.0005023007,0.000009449992,0.00002461511,0.0002827985],"genre_scores_gemma":[0.9960835,0.001208896,0.0008164105,0.0002356172,0.000104017,0.00008446616,0.00003877066,0.0000216959,0.001406607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03756111,"threshold_uncertainty_score":0.4248467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132852367346976,"score_gpt":0.2078693563273116,"score_spread":0.194584119592614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}