{"id":"W2035838135","doi":"10.1371/journal.pone.0073296","title":"The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis (RIP)","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Karolinska Institutet; McGill University","keywords":"Ectodomain; ADAM10; Cell biology; Disintegrin; Biology; Chemistry; Biochemistry; Receptor; Metalloproteinase; Matrix metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761774,0.0003134347,0.0001981056,0.000212529,0.0001289295,0.0003771132,0.0001279552,0.0002512606,0.0006154212],"category_scores_gemma":[0.0001292804,0.0001537444,0.0002994624,0.0001349533,0.0001995563,0.0002096911,0.0001678927,0.000311401,0.0004229594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561071,"about_ca_system_score_gemma":0.0001859837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007476531,"about_ca_topic_score_gemma":0.0007540567,"domain_scores_codex":[0.9998767,0.00001489045,0.000009402932,0.00002760836,0.00003218839,0.00003911277],"domain_scores_gemma":[0.9998951,0.00001764806,0.00003510661,0.0000136149,0.00001673854,0.00002172047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005438846,0.000009578231,0.0004701144,0.0000237928,0.000004726728,0.0001948036,0.0000200683,0.00003992773,0.9976276,0.0001444506,0.00004772338,0.001362912],"study_design_scores_gemma":[0.000009761271,0.0001694499,0.01064315,0.000005836932,0.00001512157,0.001539175,0.00005771111,0.0007436533,0.9824823,0.00006989021,0.004256475,0.000007552412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923316,0.001906478,0.003963236,0.00006874596,0.0000262005,0.0000214284,0.0002917448,0.00006301744,0.001327622],"genre_scores_gemma":[0.993686,0.0009035282,0.002199713,0.00004233532,0.000008119866,0.00001715137,0.0006734633,0.00001032662,0.002459283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007476531,"threshold_uncertainty_score":0.002583742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132852367346976,"score_gpt":0.2078693563273116,"score_spread":0.194584119592614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}