{"id":"W2035844629","doi":"10.1182/blood-2003-10-3531","title":"Hemophilia gene therapy: it's a matter of expression","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Factor IX; Medicine; Clotting factor; Clinical trial; Gene; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002243442,0.0002810581,0.0006542553,0.0002965819,0.0005399228,0.003140151,0.0005051365,0.00162922,0.004418053],"category_scores_gemma":[0.002624115,0.000107536,0.0001714379,0.0005259649,0.002527306,0.002459394,0.0005592798,0.002450645,0.001921726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008757527,"about_ca_system_score_gemma":0.0007867208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005803453,"about_ca_topic_score_gemma":0.0005785872,"domain_scores_codex":[0.9988298,0.0002807227,0.00004900671,0.0001129545,0.000660534,0.00006705799],"domain_scores_gemma":[0.9990681,0.0004508777,0.0001339638,0.0000763075,0.0001823065,0.00008846542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003170329,0.0001452541,0.001993196,0.00157302,0.00003716501,0.0005507783,0.00100986,0.0003279266,0.07061749,0.2068461,0.1707538,0.5458285],"study_design_scores_gemma":[0.0000326278,0.0004727845,0.001423534,0.0004785711,0.00005549053,0.004513999,0.0005299652,0.0003870962,0.02225275,0.03398361,0.9358373,0.00003234031],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02101336,0.590252,0.03020501,0.2995614,0.0185263,0.00005306274,0.0001881419,0.0004956193,0.03970508],"genre_scores_gemma":[0.2336516,0.5676393,0.01906294,0.06508803,0.0228768,0.0001026139,0.0004004136,0.0005282887,0.09065007],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004418053,"threshold_uncertainty_score":0.01477981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585532912509735,"score_gpt":0.2764092447509138,"score_spread":0.2605539156258164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}