{"id":"W2035873332","doi":"10.1152/ajpcell.00071.2009","title":"Mechanisms of human complement factor B induction in sepsis and inhibition by activated protein C","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lipopolysaccharide; Tumor necrosis factor alpha; Molecular biology; Peripheral blood mononuclear cell; Biology; Interferon gamma; Monocyte; Septic shock; Sepsis; Immunology; Cytokine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796196,0.0002626302,0.0009159373,0.0003047952,0.00009175501,0.000004011955,0.0002084423,0.0001191761,0.0003422214],"category_scores_gemma":[0.00002527554,0.0002300538,0.0001338429,0.0002475802,0.0004799297,0.0001297305,0.00007081506,0.0003659172,0.000007943042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007920135,"about_ca_system_score_gemma":0.00004949093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202091,"about_ca_topic_score_gemma":0.000005481948,"domain_scores_codex":[0.9976034,0.000752296,0.0008825768,0.0003268841,0.00006362144,0.0003712521],"domain_scores_gemma":[0.9980608,0.00009941641,0.00142368,0.0002256094,0.0001446575,0.00004587173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004948326,0.0006527326,0.00009677694,0.00003062563,0.00009986277,0.000001002122,0.0002486533,0.00001674511,0.9963666,0.0002717157,0.0007939185,0.0009265934],"study_design_scores_gemma":[0.002083115,0.005225406,0.07429424,0.00009582877,0.00003241468,0.00001196429,0.00087419,0.000001575094,0.9119225,0.005124917,0.000136004,0.0001978506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988933,0.0002169846,0.00005704483,0.0002195587,0.0001256631,0.0003599952,0.00008388011,0.00001628431,0.00002735527],"genre_scores_gemma":[0.9994744,0.00001999635,0.0001381042,0.0001596301,0.0000296239,0.00001298768,0.0001298663,0.00001390162,0.00002146852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08444405,"threshold_uncertainty_score":0.938132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263628196919932,"score_gpt":0.2574798355743824,"score_spread":0.244843553605183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}