{"id":"W2035894198","doi":"10.1002/biot.201400390","title":"Large‐scale adenovirus and poxvirus‐vectored vaccine manufacturing to enable clinical trials","year":2015,"lang":"en","type":"review","venue":"Biotechnology Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Viral vector; Virology; Vector (molecular biology); Heterologous; Biology; Computational biology; Modified vaccinia Ankara; Vaccinia; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001746499,0.0008288295,0.001010034,0.002083402,0.0002096511,0.00105118,0.00103476,0.001227621,0.003942964],"category_scores_gemma":[0.001029625,0.0004417483,0.0007005603,0.00146607,0.0005182015,0.001420947,0.0005986911,0.00208604,0.00296654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053336,"about_ca_system_score_gemma":0.001364859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006702946,"about_ca_topic_score_gemma":0.0009714405,"domain_scores_codex":[0.9994594,0.00008283975,0.00005162587,0.00007019216,0.0002981078,0.00003779811],"domain_scores_gemma":[0.9993892,0.0002676471,0.00008415715,0.00003053504,0.0001867135,0.00004186664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007583945,0.0001330979,0.0002040122,0.01528989,0.00009154895,0.0002292318,0.00006676443,0.0008687008,0.01725876,0.01232374,0.02424864,0.9292098],"study_design_scores_gemma":[0.00001859714,0.0001358531,0.0003360581,0.0009030658,0.00005283014,0.0006420586,0.00001880308,0.0001400217,0.00525204,0.001378212,0.9911068,0.00001575771],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005975493,0.9897206,0.003810456,0.0003940564,0.0005290657,0.00008471883,0.00007115967,0.00003997292,0.004752369],"genre_scores_gemma":[0.003338993,0.9882563,0.004248505,0.0003473248,0.0001715957,0.00008694074,0.0001539186,0.000008942699,0.003387469],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003942964,"threshold_uncertainty_score":0.01319051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327102923135172,"score_gpt":0.4576559908706941,"score_spread":0.3249456985571769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}