{"id":"W2035894198","doi":"10.1002/biot.201400390","title":"Large‐scale adenovirus and poxvirus‐vectored vaccine manufacturing to enable clinical trials","year":2015,"lang":"en","type":"review","venue":"Biotechnology Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Viral vector; Virology; Vector (molecular biology); Heterologous; Biology; Computational biology; Modified vaccinia Ankara; Vaccinia; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.01086256,0.0006465455,0.002840894,0.0006447512,0.0002474482,0.000121774,0.001113306,0.002959651,0.0001238024],"category_scores_gemma":[0.001497568,0.0004969512,0.0007575685,0.0002657736,0.0001394324,0.0000072557,0.0008828071,0.00213884,0.0001559225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155778,"about_ca_system_score_gemma":0.0008471396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003010725,"about_ca_topic_score_gemma":0.00006817757,"domain_scores_codex":[0.9939108,0.001884702,0.001914892,0.000967591,0.0003619922,0.0009599786],"domain_scores_gemma":[0.9971769,0.0001413425,0.0008571925,0.001019743,0.0001527651,0.0006520755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009374102,0.000126687,0.000007975238,0.00032979,0.0007615208,0.00008966197,0.00001359025,8.708358e-7,0.003656552,0.000004568293,0.01613288,0.9779385],"study_design_scores_gemma":[0.001506244,0.003354325,0.000003124004,0.0005527472,0.0003344236,0.001135519,0.00004452064,9.333102e-7,0.01496278,0.00008611197,0.9775164,0.000502867],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01061517,0.9866071,0.0002709259,0.0006065783,0.000676551,0.0009760725,0.0001349762,0.00005286359,0.00005977004],"genre_scores_gemma":[0.0001743336,0.9960352,0.0006604125,0.0002319506,0.001966552,0.00005609977,0.00007738928,0.0001272758,0.0006707601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9774356,"threshold_uncertainty_score":0.9997482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327102923135172,"score_gpt":0.4576559908706941,"score_spread":0.3249456985571769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}