{"id":"W2035894835","doi":"10.1186/s13058-015-0551-x","title":"FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth","year":2015,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Université de Montréal; Susan G. Komen; Servier; Ovarian Cancer Research Fund; American Heart Association","keywords":"Focal adhesion; Nucleolin; Protein kinase B; Cell biology; Cancer research; PI3K/AKT/mTOR pathway; Biology; Small hairpin RNA; Cell growth; Signal transduction; Molecular biology; Nucleolus; Gene knockdown; Apoptosis; Cytoplasm; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002259926,0.0002671335,0.0004815063,0.0003723285,0.0001612745,0.0001069601,0.0002838422,0.0001365711,0.0006908807],"category_scores_gemma":[0.0005232046,0.0002334462,0.00006206966,0.001420483,0.0004506335,0.0002439143,0.0005070085,0.001480626,0.000104008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001402023,"about_ca_system_score_gemma":0.001741257,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0428222,"about_ca_topic_score_gemma":0.003256865,"domain_scores_codex":[0.9949439,0.0006044058,0.0003176233,0.0008287367,0.002095028,0.001210307],"domain_scores_gemma":[0.9971008,0.0002533754,0.00006418559,0.0004620615,0.001178102,0.000941472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006274452,0.0006949825,0.2132237,0.001972018,0.00009486908,0.0009999005,0.002377324,0.00002394162,0.2962261,0.00003749577,0.004443938,0.4736312],"study_design_scores_gemma":[0.006736245,0.0004268185,0.9603842,0.001526615,0.00001656417,0.001272651,0.002939829,0.002234148,0.02255907,0.000129832,0.001295106,0.0004788948],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869677,0.0009614822,0.00001118527,0.008343439,0.00005275941,0.00182097,0.0002316459,0.00005614457,0.001554652],"genre_scores_gemma":[0.9968327,0.0001860263,0.0001488045,0.0001043385,0.0002472711,0.0009419781,0.000004617672,0.00007066587,0.001463626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7471605,"threshold_uncertainty_score":0.9635517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08267294748368507,"score_gpt":0.4005178804354456,"score_spread":0.3178449329517605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}