{"id":"W2035894835","doi":"10.1186/s13058-015-0551-x","title":"FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth","year":2015,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Université de Montréal; Susan G. Komen; Servier; Ovarian Cancer Research Fund; American Heart Association","keywords":"Focal adhesion; Nucleolin; Protein kinase B; Cell biology; Cancer research; PI3K/AKT/mTOR pathway; Biology; Small hairpin RNA; Cell growth; Signal transduction; Molecular biology; Nucleolus; Gene knockdown; Apoptosis; Cytoplasm; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008380786,0.0002945682,0.0002269973,0.0001655667,0.0001568381,0.0001640653,0.0001432427,0.0002160044,0.002072862],"category_scores_gemma":[0.00007526198,0.0001044737,0.000191824,0.0001193176,0.0001457217,0.000117225,0.0001174769,0.0003443553,0.0004462686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389444,"about_ca_system_score_gemma":0.0002342254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005009644,"about_ca_topic_score_gemma":0.000873709,"domain_scores_codex":[0.9999261,0.000009613529,0.000005656285,0.00001545248,0.00002226114,0.00002099321],"domain_scores_gemma":[0.9999542,0.00000675697,0.00001268896,0.000006340925,0.00000589792,0.00001423985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002448145,0.00003248845,0.00009186061,0.00007686896,0.000006666193,0.00002934303,0.00001164124,0.00003764193,0.997816,0.000109542,0.0001478296,0.001395285],"study_design_scores_gemma":[0.00002700934,0.0002756779,0.003160775,0.00000981986,0.00001477113,0.0002133143,0.00001616917,0.0003043543,0.9915383,0.00004160055,0.004394074,0.000004013084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891746,0.003895459,0.002005155,0.0001769146,0.00007425904,0.00005583939,0.001079217,0.0001356675,0.0034029],"genre_scores_gemma":[0.9911489,0.001755698,0.001872962,0.00006076605,0.00001693799,0.00006807331,0.001465275,0.00003134687,0.003580113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072862,"threshold_uncertainty_score":0.006934464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08267294748368507,"score_gpt":0.4005178804354456,"score_spread":0.3178449329517605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}