{"id":"W2036006795","doi":"10.1016/j.chembiol.2012.04.003","title":"Designing Chimeric LOV Photoswitches","year":2012,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health","keywords":"Chemical biology; Computational biology; Structural biology; Biology; Synthetic biology; Biophysics; Fusion protein; Helix (gastropod); Nanotechnology; Recombinant DNA; Cell biology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000472644,0.0003116237,0.0003852425,0.00009409886,0.0005729404,0.0009317088,0.0005869578,0.001751577,0.002663849],"category_scores_gemma":[0.0008210361,0.0003135471,0.0003200669,0.00011809,0.0005621393,0.001032881,0.000605561,0.003390756,0.001378064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009038186,"about_ca_system_score_gemma":0.0002881363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003615954,"about_ca_topic_score_gemma":0.0007610966,"domain_scores_codex":[0.9998447,0.00002319627,0.00001117361,0.00003165991,0.00004191362,0.00004730662],"domain_scores_gemma":[0.999729,0.0001400023,0.00002410105,0.00003257421,0.00002184807,0.00005255094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007022101,0.0002938429,0.0005940202,0.0004874519,0.00004520599,0.002863654,0.0005431917,0.002939328,0.8359427,0.0596512,0.03974277,0.05619428],"study_design_scores_gemma":[0.0002619244,0.0004245007,0.0002586377,0.00002795537,0.00003810762,0.001081513,0.0002090013,0.009253283,0.7744784,0.01021516,0.2036801,0.00007137129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6739808,0.01398424,0.1281826,0.08537302,0.0122307,0.0006105023,0.0009992378,0.005306681,0.07933219],"genre_scores_gemma":[0.8990079,0.003893093,0.04471213,0.01673129,0.000581203,0.0003693257,0.0004245763,0.0004460662,0.03383443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002663849,"threshold_uncertainty_score":0.00891149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06935334402535555,"score_gpt":0.315689200351886,"score_spread":0.2463358563265304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}