{"id":"W2036044162","doi":"10.12703/p5-45","title":"Sumoylation in gene regulation, human disease, and therapeutic action","year":2013,"lang":"en","type":"review","venue":"F1000Prime Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Prevention and Research Institute of Texas","keywords":"SUMO protein; Action (physics); Gene; Disease; Genetic enhancement; Biology; Computational biology; Genetics; Medicine; Ubiquitin; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006894299,0.0008275463,0.001172413,0.001738383,0.0003289178,0.0008637111,0.00090257,0.00141364,0.00392885],"category_scores_gemma":[0.0004884746,0.0002448619,0.0003508054,0.001798674,0.001016236,0.001362174,0.0008483172,0.001852696,0.003635141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007993768,"about_ca_system_score_gemma":0.0008263419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000653212,"about_ca_topic_score_gemma":0.001134314,"domain_scores_codex":[0.9997928,0.0000392144,0.00002797618,0.00003611455,0.00007854597,0.00002538932],"domain_scores_gemma":[0.9998344,0.00006564637,0.00002385476,0.000009748487,0.00003704686,0.00002924963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007429348,0.0000561908,0.0001313445,0.00814114,0.00004282331,0.0003718736,0.0000739089,0.0002648784,0.003130942,0.008230364,0.04641132,0.933071],"study_design_scores_gemma":[0.00000949148,0.00003788089,0.0002879443,0.0008817254,0.00001845938,0.001022301,0.00003211521,0.00002852387,0.0003813806,0.002190048,0.9951016,0.000008535553],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007809595,0.9973586,0.0001376478,0.0003051989,0.0003496803,0.000003782808,0.000009601693,0.000009319992,0.001748051],"genre_scores_gemma":[0.0007936732,0.9973157,0.0001954743,0.0002288842,0.0002898148,0.000007223523,0.00001969277,0.000002132002,0.001147349],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00392885,"threshold_uncertainty_score":0.0131433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05871314154717096,"score_gpt":0.3360138498175365,"score_spread":0.2773007082703655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}