{"id":"W2036051372","doi":"10.1902/jop.2002.73.1.79","title":"Inhibition of Proteolytic, Serpinolytic, and Progelatinase‐B Activation Activities of Periodontopathogens by Doxycycline and the Non‐Antimicrobial Chemically Modified Tetracycline Derivatives","year":2002,"lang":"en","type":"article","venue":"Journal of Periodontology","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research","keywords":"Treponema denticola; Doxycycline; Porphyromonas gingivalis; Chemistry; Matrix metalloproteinase; Antimicrobial; Trypsin; Proteolytic enzymes; Streptococcus mutans; Microbiology; Tetracycline; Biochemistry; Enzyme; Biology; Antibiotics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006235236,0.0002226972,0.000856334,0.0001720951,0.0001451803,0.00003950273,0.0001783161,0.000297428,0.0002175878],"category_scores_gemma":[0.0004774104,0.0001574482,0.0001526611,0.0001487592,0.001744689,0.000350637,0.0001102464,0.0005428201,0.000001631908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003231662,"about_ca_system_score_gemma":0.00005373231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007457575,"about_ca_topic_score_gemma":0.00006877416,"domain_scores_codex":[0.9979884,0.000338609,0.0009748488,0.0002274629,0.0001962787,0.0002744033],"domain_scores_gemma":[0.9980717,0.000349687,0.001011908,0.0001839642,0.0003066117,0.00007614662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001667345,0.0002378484,0.01493013,0.0002058885,0.0001492176,0.00002252777,0.002306078,0.000003859042,0.9769514,0.0001186803,0.0004458573,0.002961224],"study_design_scores_gemma":[0.01008868,0.000977102,0.04844721,0.0003071239,0.0001546987,0.002254826,0.001135038,0.0008223069,0.9348248,0.0001587206,0.0005212481,0.0003083143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961849,0.001027993,0.0005402467,0.001233567,0.0001043832,0.0005592295,0.00006375938,0.000006124319,0.0002797576],"genre_scores_gemma":[0.9979185,0.0004724494,0.00105028,0.00006656443,0.00008598143,0.00001350596,0.000008525879,0.00001776226,0.0003663545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04212661,"threshold_uncertainty_score":0.642838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494141481241387,"score_gpt":0.2584494901397731,"score_spread":0.2435080753273593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}