{"id":"W2036051372","doi":"10.1902/jop.2002.73.1.79","title":"Inhibition of Proteolytic, Serpinolytic, and Progelatinase‐B Activation Activities of Periodontopathogens by Doxycycline and the Non‐Antimicrobial Chemically Modified Tetracycline Derivatives","year":2002,"lang":"en","type":"article","venue":"Journal of Periodontology","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Dental and Craniofacial Research","keywords":"Treponema denticola; Doxycycline; Porphyromonas gingivalis; Chemistry; Matrix metalloproteinase; Antimicrobial; Trypsin; Proteolytic enzymes; Streptococcus mutans; Microbiology; Tetracycline; Biochemistry; Enzyme; Biology; Antibiotics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241677,0.0002497516,0.0001505938,0.00009866435,0.00007004917,0.0001272214,0.00009806966,0.0001348118,0.0008262647],"category_scores_gemma":[0.0001539311,0.00007546457,0.0001302033,0.00008056169,0.0001831684,0.0001003468,0.0001098629,0.0002710029,0.0001185135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001806758,"about_ca_system_score_gemma":0.0001722356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003991686,"about_ca_topic_score_gemma":0.001000488,"domain_scores_codex":[0.9998931,0.00002301427,0.00001408025,0.00002190731,0.00002552015,0.00002238086],"domain_scores_gemma":[0.9998502,0.00003856986,0.00005997014,0.00001172544,0.00001146193,0.00002812364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775059,0.00002836305,0.0001921479,0.00007177729,0.000004858188,0.00002145083,0.000006117172,0.00003983081,0.9974049,0.00001467313,0.00001515439,0.0020232],"study_design_scores_gemma":[0.00003178883,0.0009269085,0.006702341,0.000007842211,0.0000121038,0.0001835744,0.00000944862,0.0002603192,0.9902624,0.000007346603,0.00159306,0.000002821212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925068,0.005626857,0.0009097531,0.00004901223,0.0000120555,0.00003100628,0.0001608213,0.00001816454,0.0006855071],"genre_scores_gemma":[0.9948878,0.001876467,0.002111912,0.00002856523,0.000009687905,0.00003799329,0.0002354806,0.000006224265,0.000805754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008262647,"threshold_uncertainty_score":0.002764165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494141481241387,"score_gpt":0.2584494901397731,"score_spread":0.2435080753273593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}