{"id":"W2036094813","doi":"10.1111/j.1349-7006.2007.00707.x","title":"Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells","year":2008,"lang":"en","type":"article","venue":"Cancer Science","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Terry Fox Foundation","keywords":"Ionizing radiation; Basal cell; Cancer research; Triad (sociology); Histidine; Radiation therapy; Carcinoma; Medicine; Cell; Pathology; Biology; Internal medicine; Irradiation; Biochemistry; Enzyme; Psychology; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066939,0.0003839735,0.0002973648,0.0002821535,0.0001656127,0.0003108543,0.0002557198,0.0003037546,0.001698103],"category_scores_gemma":[0.00009353463,0.0002266028,0.0003169272,0.0002485868,0.0002171254,0.0001527991,0.0001976311,0.0005951744,0.0005020421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002906958,"about_ca_system_score_gemma":0.0002484948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574411,"about_ca_topic_score_gemma":0.001385535,"domain_scores_codex":[0.999859,0.0000113071,0.00002043527,0.00002686096,0.00004174588,0.00004073872],"domain_scores_gemma":[0.9998765,0.00001618955,0.00003076863,0.00002427777,0.000009752942,0.00004247193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009509783,0.00002453854,0.00008892286,0.00001742852,0.000004879232,0.00004169898,0.00001215178,0.00004638682,0.9991606,0.00004638345,0.00002766647,0.0004341855],"study_design_scores_gemma":[0.00002541934,0.0003472315,0.007526156,0.000005097855,0.0000214733,0.0001918459,0.00005901156,0.0008545867,0.989116,0.00003309955,0.001812329,0.000007709557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971278,0.0004238728,0.0008687594,0.00004153278,0.00002866892,0.00002537957,0.0005761256,0.0001184374,0.0007895068],"genre_scores_gemma":[0.9962346,0.0003199048,0.0004948346,0.00002826184,0.000005042335,0.00003157061,0.0006917266,0.00002359641,0.002170631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698103,"threshold_uncertainty_score":0.00568074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996649876464368,"score_gpt":0.2656936508001482,"score_spread":0.2457271520355045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}