{"id":"W2036120792","doi":"10.1002/jbmr.168","title":"Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways","year":2010,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Catenin; Glucocorticoid; Apoptosis; Cell biology; Signal transduction; Chemistry; Internal medicine; Endocrinology; Biology; Medicine; Wnt signaling pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001193549,0.00008639364,0.0001988238,0.00009726123,0.00006144444,0.00002372269,0.00008743341,0.0002228907,0.00000411896],"category_scores_gemma":[0.0003014299,0.00005307015,0.00006368274,0.0001453727,0.0001234028,0.00001265932,0.0001087538,0.000750555,4.6783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006698647,"about_ca_system_score_gemma":0.0001125163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007784768,"about_ca_topic_score_gemma":0.00003025616,"domain_scores_codex":[0.9989398,0.0001390122,0.0003157114,0.0001402714,0.0002552726,0.0002099094],"domain_scores_gemma":[0.9994324,0.00007735183,0.0001246638,0.0001287546,0.0001625678,0.00007429392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676006,0.00007132095,0.0006657564,0.00001578874,0.00003654982,0.000006818536,0.000152132,0.000001709755,0.9942081,0.0001558836,0.0003453376,0.004072986],"study_design_scores_gemma":[0.001060357,0.001525128,0.002592394,0.00003949031,0.00001783979,0.000233767,0.0003629609,0.00005136778,0.9931087,0.0003232244,0.0006133592,0.00007140993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975336,0.001445,0.000006305806,0.0005895114,0.0001251081,0.000140994,0.000001519113,9.328674e-7,0.0001569967],"genre_scores_gemma":[0.9980589,0.001392784,0.0002029398,0.00002546813,0.0002019584,0.000003807562,0.000002038402,0.000009170953,0.0001029624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004001576,"threshold_uncertainty_score":0.326083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0336501375563305,"score_gpt":0.3172628392473223,"score_spread":0.2836127016909918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}