{"id":"W2036123840","doi":"10.1159/000101049","title":"Heterogeneous Expression of Claudin-4 in Human Colorectal Cancer: Decreased Claudin-4 Expression at the Invasive Front Correlates Cancer Invasion and Metastasis","year":2007,"lang":"en","type":"article","venue":"Pathobiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Claudin; Gene knockdown; Metastasis; Colorectal cancer; Small interfering RNA; Cancer research; Tight junction; Downregulation and upregulation; Immunohistochemistry; Cancer; Medicine; Biology; Transfection; Cell culture; Pathology; Internal medicine; Cell biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813863,0.0001782409,0.0002144422,0.0008540884,0.0002391354,0.0002709329,0.0001370696,0.0002523026,0.0009401624],"category_scores_gemma":[0.000367596,0.0001329955,0.0001592442,0.0005516042,0.0002537804,0.0002595336,0.0002317728,0.0002254325,0.0001631187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002270795,"about_ca_system_score_gemma":0.000176703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009012681,"about_ca_topic_score_gemma":0.0006962601,"domain_scores_codex":[0.9998814,0.00001750676,0.00001001788,0.00003386058,0.00003081859,0.00002636003],"domain_scores_gemma":[0.9998117,0.00003004464,0.00008362529,0.00001298274,0.00003096191,0.00003065385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008117402,0.00005220098,0.09915659,0.00019311,0.00005658986,0.0005170227,0.0001130531,0.0002049896,0.8913252,0.0001347125,0.0001390617,0.007295675],"study_design_scores_gemma":[0.00003653386,0.0005252156,0.7998916,0.00001979772,0.000195663,0.002755722,0.0002761151,0.001669592,0.1916402,0.0002623594,0.002707105,0.00002007724],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966531,0.001974178,0.0009079567,0.00003303509,0.000004175009,0.000008417544,0.0001113538,0.00002483779,0.0002829887],"genre_scores_gemma":[0.9985664,0.0005210293,0.0004047988,0.00001399346,0.000005222038,0.000009002794,0.0001672183,0.000003768158,0.0003086046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009401624,"threshold_uncertainty_score":0.003145218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02766232987101207,"score_gpt":0.2876123583870591,"score_spread":0.259950028516047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}