{"id":"W2036143444","doi":"10.3389/fphar.2013.00126","title":"Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation","year":2013,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université Laval; University of British Columbia; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"Long QT syndrome; Mutation; Sodium channel; Brugada syndrome; Medicine; Torsades de pointes; QT interval; Sudden cardiac death; Internal medicine; Repolarization; Cardiology; Genetics; Biology; Gene; Chemistry; Electrophysiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367912,0.0003144691,0.0002841837,0.0002205395,0.0001672513,0.0001291816,0.0001673595,0.0004379498,0.001512995],"category_scores_gemma":[0.0002677729,0.00008906692,0.0004219126,0.0001144346,0.000216129,0.0001246808,0.0001731135,0.0002877909,0.0002637096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437282,"about_ca_system_score_gemma":0.000116456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003498463,"about_ca_topic_score_gemma":0.0002648649,"domain_scores_codex":[0.9999056,0.00001769438,0.0000124649,0.00002654326,0.00002790622,0.000009732312],"domain_scores_gemma":[0.9998995,0.00002652344,0.00002258832,0.000008405583,0.00001165483,0.00003118746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230076,0.00003174752,0.001400074,0.00002916438,0.00001323237,0.002750962,0.00004677817,0.00007965107,0.9937017,0.00008946389,0.00006911065,0.001665219],"study_design_scores_gemma":[0.000285713,0.002436439,0.1079059,0.00005821198,0.0002432523,0.06629718,0.000198232,0.008921834,0.8049167,0.0008094094,0.007874354,0.00005267578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969937,0.000260409,0.001949174,0.0001056142,0.00002650284,0.00001561749,0.0001612245,0.00006303486,0.0004247375],"genre_scores_gemma":[0.9976761,0.0001836866,0.001233981,0.00008730711,0.00002020267,0.00001665332,0.000203649,0.00002496779,0.000553405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512995,"threshold_uncertainty_score":0.005061507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280585273137862,"score_gpt":0.2722184911663924,"score_spread":0.2594126384350138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}