{"id":"W2036144913","doi":"10.1111/apt.12940","title":"Adalimumab dose escalation is effective for managing secondary loss of response in Crohn's disease","year":2014,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Janssen Canada; AbbVie Canada; Alberta Innovates - Health Solutions; AbbVie","keywords":"Adalimumab; Medicine; Internal medicine; Crohn's disease; Retrospective cohort study; Univariate analysis; Gastroenterology; Disease; Surgery; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002642674,0.0002853783,0.0007644715,0.000514151,0.0002459848,0.0006357082,0.0003606117,0.0002850126,0.0009646707],"category_scores_gemma":[0.003851146,0.0001396802,0.0007567916,0.0004255969,0.0001962702,0.0003891312,0.0003657307,0.00083266,0.0003019607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003914114,"about_ca_system_score_gemma":0.0002742284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001793329,"about_ca_topic_score_gemma":0.0003112386,"domain_scores_codex":[0.998223,0.0007946907,0.0002443875,0.0001647032,0.0004385354,0.0001346515],"domain_scores_gemma":[0.9979329,0.0006776199,0.0009263579,0.000200576,0.0001339016,0.000128594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.009228525,0.0027271,0.2085111,0.001235821,0.0007417842,0.0006922083,0.0005205317,0.002362642,0.03006972,0.0002479256,0.002333006,0.7413296],"study_design_scores_gemma":[0.002196742,0.03762395,0.9039881,0.0006588036,0.0009976825,0.00773074,0.0002907955,0.00859705,0.01789528,0.0008403291,0.01912326,0.00005741095],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844434,0.01016372,0.002299784,0.0002969746,0.00004605982,0.0001707763,0.000106663,0.0001110917,0.00236154],"genre_scores_gemma":[0.9974209,0.001013242,0.001083071,0.0001120968,0.0000398029,0.00005376901,0.00008154719,0.000008246476,0.0001872586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002642674,"threshold_uncertainty_score":0.01397598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086841898356109,"score_gpt":0.2916251447896521,"score_spread":0.2829409549540411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}