{"id":"W2036181649","doi":"10.1002/cbic.200500540","title":"Assessing the Structural Stability of Designed β‐Hairpin Peptides in the Cytoplasm of Live Cells","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Research Chairs; University of Alberta","keywords":"Förster resonance energy transfer; Cytoplasm; In vitro; Fluorescence; Green fluorescent protein; Peptide; In vivo; Biophysics; Protein stability; Chemistry; Genetically engineered; Cell biology; Biology; Computational biology; Biochemistry; Gene; Genetics; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003960909,0.0002101001,0.0002318221,0.00007443397,0.0001820709,0.0002621931,0.0002456607,0.0003731183,0.0005536996],"category_scores_gemma":[0.0005793772,0.0001375948,0.0001322317,0.00008716479,0.0002849751,0.000282741,0.0001312136,0.0006528146,0.0001882621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178674,"about_ca_system_score_gemma":0.0001573209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431567,"about_ca_topic_score_gemma":0.0004432863,"domain_scores_codex":[0.9998444,0.00003648658,0.00001061954,0.00004447194,0.0000453227,0.00001862578],"domain_scores_gemma":[0.9995844,0.0002091354,0.00007862844,0.00002735587,0.00006293869,0.00003762853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000163737,0.000004579773,0.00004838291,0.000006335849,0.000001320428,0.000008729773,0.00001440663,0.00004880802,0.9996837,0.0000299174,0.00000392416,0.0001335708],"study_design_scores_gemma":[0.000004746275,0.00008170254,0.0005132679,0.000001927,0.000004479285,0.00004089503,0.0000147755,0.001047937,0.9980409,0.00002495735,0.0002218655,0.000002537476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872043,0.0003979742,0.01166485,0.00004323713,0.000014584,0.00001202043,0.0001146732,0.00005167508,0.0004967689],"genre_scores_gemma":[0.9884993,0.0002952228,0.009912703,0.00004269388,0.000004159756,0.00003969042,0.0002879514,0.00003664692,0.0008816389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005536996,"threshold_uncertainty_score":0.002306342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570757300414619,"score_gpt":0.2549314977534154,"score_spread":0.2392239247492692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}