{"id":"W2036181958","doi":"10.1016/j.toxicon.2006.11.023","title":"Isolation, characterization and pentamerization of α-cobrotoxin specific single-domain antibodies from a naïve phage display library: Preliminary findings for antivenom development","year":2006,"lang":"en","type":"article","venue":"Toxicon","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences; University of Guelph","funders":"","keywords":"Venom; Neutralization; Antivenom; Recombinant DNA; Neurotoxin; Antibody; Toxin; Phage display; Snake venom; Biodistribution; Molecular biology; Biology; Virology; Chemistry; Microbiology; Biochemistry; Immunology; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004757211,0.0001206264,0.0001484006,0.0000432459,0.0001150066,0.00002976608,0.00005157411,0.00006512751,0.00001352192],"category_scores_gemma":[0.000009513122,0.0001218928,0.00003291059,0.00004963723,0.00006006425,0.00002237588,0.00005228956,0.00002059305,0.000001526744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008676337,"about_ca_system_score_gemma":0.00001815991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004092351,"about_ca_topic_score_gemma":0.000003214026,"domain_scores_codex":[0.9993271,0.00002340865,0.0002477497,0.0002298327,0.00006201451,0.000109884],"domain_scores_gemma":[0.9997175,0.00001388217,0.0001340813,0.00008098432,0.00003301305,0.00002052248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001982411,0.0001077464,0.01880583,0.00003018484,0.00002484033,3.723059e-7,0.0003514327,0.000003788412,0.9786055,0.0003344206,0.0001628835,0.001374755],"study_design_scores_gemma":[0.0005247357,0.0003078992,0.3004189,0.00003165277,0.000009488636,0.000001277327,0.0001160298,0.0001170327,0.684315,0.0001049581,0.01390577,0.0001472621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556884,0.0003659184,0.04310786,0.00007750311,0.00004267766,0.000347177,0.0001456608,0.00001404935,0.0002108092],"genre_scores_gemma":[0.9908544,0.00009276086,0.005815494,0.00003834762,0.0001031358,0.00002642615,0.002667862,0.00001920997,0.00038234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2942905,"threshold_uncertainty_score":0.4970644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008997339297395908,"score_gpt":0.2087401153707783,"score_spread":0.1997427760733824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}