{"id":"W2036181958","doi":"10.1016/j.toxicon.2006.11.023","title":"Isolation, characterization and pentamerization of α-cobrotoxin specific single-domain antibodies from a naïve phage display library: Preliminary findings for antivenom development","year":2006,"lang":"en","type":"article","venue":"Toxicon","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences; University of Guelph","funders":"","keywords":"Venom; Neutralization; Antivenom; Recombinant DNA; Neurotoxin; Antibody; Toxin; Phage display; Snake venom; Biodistribution; Molecular biology; Biology; Virology; Chemistry; Microbiology; Biochemistry; Immunology; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378509,0.0003914556,0.0003517616,0.0002543935,0.0002196434,0.0004314408,0.0002743092,0.0002913723,0.00116329],"category_scores_gemma":[0.0003295964,0.0001914125,0.0002712888,0.000212694,0.0001212503,0.0001575143,0.0002692655,0.000871891,0.0006975437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802858,"about_ca_system_score_gemma":0.0001683319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539539,"about_ca_topic_score_gemma":0.00121469,"domain_scores_codex":[0.9997886,0.00002858313,0.00001793479,0.00005215812,0.00004684814,0.00006601269],"domain_scores_gemma":[0.9997879,0.00006285666,0.00002299356,0.00003433547,0.00004631168,0.00004553502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002658368,0.00002492133,0.0001020647,0.000007604797,0.000002376796,0.00001336111,0.00001048133,0.00004297385,0.9989243,0.00002096292,0.00002098044,0.0008033558],"study_design_scores_gemma":[0.00001313442,0.0001970976,0.003241068,0.000002208365,0.00001838823,0.0002376537,0.00002019201,0.001095876,0.9938357,0.00003388357,0.001300738,0.000004037636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667905,0.000343117,0.03008258,0.0001229444,0.00002323344,0.0001556171,0.0005447175,0.000109223,0.001828009],"genre_scores_gemma":[0.9720129,0.000597366,0.01657564,0.0003008404,0.00001949603,0.0001053057,0.003678341,0.000105373,0.006604812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116329,"threshold_uncertainty_score":0.003891647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008997339297395908,"score_gpt":0.2087401153707783,"score_spread":0.1997427760733824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}