{"id":"W2036185981","doi":"10.1073/pnas.0813296106","title":"Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Leukemia and Lymphoma Society; Canadian Institutes of Health Research; Deutsche Krebshilfe; National Cancer Institute; National Institutes of Health; Cancer Research Institute","keywords":"NFAT; Calcineurin; Biology; Cell biology; Transcription factor; Embryonic stem cell; Phosphatase; Signal transduction; Phosphorylation; Molecular biology; Transplantation; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009098488,0.00005890305,0.00007836223,0.00004835427,0.00009337751,0.0000111337,0.0002770161,0.00005361103,0.000001502076],"category_scores_gemma":[0.0003906122,0.00004604424,0.00002929251,0.0001407722,0.0001904839,0.00001065155,0.00004973335,0.00003640065,7.91147e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000196603,"about_ca_system_score_gemma":0.00007015921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.565979e-7,"about_ca_topic_score_gemma":7.468085e-8,"domain_scores_codex":[0.9991658,0.000003372397,0.000191624,0.0001827741,0.0003384167,0.000118061],"domain_scores_gemma":[0.9996885,0.00002088951,0.0001468196,0.000005872201,0.0001122521,0.00002564063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002184261,0.00002691711,0.003558936,0.00004036167,0.000004571699,2.349198e-9,0.00009826382,0.00008422759,0.9918998,0.003843193,0.0001337774,0.0002880309],"study_design_scores_gemma":[0.0002365456,0.00004890717,0.01585036,0.00009540823,0.000003684531,0.000001291714,0.00008236425,0.00008880711,0.9730082,0.0102796,0.000242412,0.00006243293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977984,0.0004091842,0.000007956902,0.001233161,0.000007637662,0.000189481,0.000003366662,0.00000211904,0.000348711],"genre_scores_gemma":[0.9955744,0.00001424492,0.004038892,0.0002771108,0.00003326417,0.00001384397,3.628844e-7,0.000002013088,0.00004591496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01889169,"threshold_uncertainty_score":0.187763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03619291705222411,"score_gpt":0.3106275037188748,"score_spread":0.2744345866666507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}