{"id":"W2036187256","doi":"10.1002/path.2076","title":"Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis","year":2006,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Kingston General Hospital; Biotechnology Research Institute","funders":"Deutsche Forschungsgemeinschaft","keywords":"Amyloidosis; Amyloid (mycology); Cathepsin B; Proteases; Amyloid disease; Cerebral amyloid angiopathy; Chemistry; P3 peptide; Cathepsin; Serum amyloid A; Amyloid precursor protein; Cathepsin D; Biochemistry; Biology; Alzheimer's disease; Immunology; Pathology; Medicine; Enzyme; Inflammation; Amyloid β; Amyloid fibril; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009107296,0.0002493623,0.0003685227,0.0001100396,0.00008327679,0.00001719593,0.0003860368,0.0002146448,0.00003178106],"category_scores_gemma":[0.0001868491,0.0001714543,0.0001986027,0.0001410063,0.0002055718,0.00001516635,0.0001152999,0.0002968285,0.00001551181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001143438,"about_ca_system_score_gemma":0.0001628682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002663402,"about_ca_topic_score_gemma":0.0004072694,"domain_scores_codex":[0.9981831,0.0004843451,0.0005061144,0.0002264219,0.0002177666,0.0003821916],"domain_scores_gemma":[0.9987897,0.00008021392,0.0005200589,0.0004051206,0.0001324582,0.0000724618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005380347,0.0007016704,0.1357007,0.00001241317,0.00007386154,0.0002315288,0.0001826453,0.0008422075,0.8573539,0.0000416722,0.001240156,0.003081297],"study_design_scores_gemma":[0.002640721,0.0009877929,0.3868507,0.00003416824,0.0001440653,0.001493329,0.0001428816,0.00005206401,0.6045228,0.0008386201,0.001963627,0.0003293227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954704,0.002021484,0.000408141,0.00141319,0.0001704779,0.000271049,0.00001456234,0.00000766421,0.0002230415],"genre_scores_gemma":[0.9979496,0.0004499291,0.0006840633,0.0002167226,0.0002930945,0.00002291694,0.000005607733,0.00003081452,0.00034726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2528311,"threshold_uncertainty_score":0.6991705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009704011532021274,"score_gpt":0.253990988745343,"score_spread":0.2442869772133218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}