{"id":"W2036285113","doi":"10.1016/s0009-2797(00)00272-6","title":"The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes","year":2001,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Air Quality and Health Impacts","field":"Environmental Science","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; University of Toronto","funders":"","keywords":"Cytotoxicity; Glutathione; Hepatocyte; Chemistry; Lipid peroxidation; Formaldehyde dehydrogenase; Biochemistry; Aldehyde dehydrogenase; Toxicity; Mitochondrion; Carcinogen; Reactive oxygen species; Enzyme; Molecular biology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357462,0.0003358552,0.0002524858,0.0004158595,0.0001984665,0.0002629321,0.000251956,0.000197934,0.001126658],"category_scores_gemma":[0.0001638959,0.0001976283,0.0003617211,0.0003221784,0.0003212766,0.0003205689,0.0001674815,0.000409466,0.0003049812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293049,"about_ca_system_score_gemma":0.0002602385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002305779,"about_ca_topic_score_gemma":0.002436895,"domain_scores_codex":[0.9998577,0.00003017743,0.00001314633,0.00002913761,0.00002855434,0.00004134028],"domain_scores_gemma":[0.9998516,0.00004945273,0.0000179634,0.00003082049,0.00002625463,0.00002391264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001798325,0.00008830727,0.00198535,0.00007475161,0.00004959441,0.0001749615,0.00006180977,0.0002777606,0.9917952,0.0002928565,0.00005012521,0.003351038],"study_design_scores_gemma":[0.00002460928,0.0004294582,0.01225928,0.000003685899,0.00006989329,0.0001584622,0.00005876408,0.0007387789,0.9855992,0.000104802,0.0005455532,0.000007564604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992009,0.003061982,0.003050725,0.00006626632,0.00004630645,0.00002130384,0.0003804921,0.00004805435,0.001315722],"genre_scores_gemma":[0.9954643,0.001038981,0.0009415193,0.00002523176,0.00001736985,0.00001970439,0.0007157143,0.00001047728,0.001766907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305779,"threshold_uncertainty_score":0.004584789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0482001873550854,"score_gpt":0.3088856258825531,"score_spread":0.2606854385274677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}