{"id":"W2036297146","doi":"10.1038/sj.clpt.6100064","title":"Safety and Pharmacokinetics of Paracetamol Following Intravenous Administration of 5 g During the First 24 h with a 2-g Starting Dose","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"ASTER","funders":"","keywords":"Pharmacokinetics; Cmin; Cmax; Medicine; Pharmacology; Analgesic; Anesthesia; Intravenous Infusions; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003449467,0.0004377668,0.0007529738,0.0001426496,0.0001904175,0.0003630271,0.0002080197,0.0004478799,0.0009074196],"category_scores_gemma":[0.0009895316,0.0002414493,0.0002768964,0.0001491788,0.0004288371,0.0002504235,0.0001195611,0.0005434736,0.0003826824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985405,"about_ca_system_score_gemma":0.0004024751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005763128,"about_ca_topic_score_gemma":0.000700396,"domain_scores_codex":[0.9995959,0.0001977228,0.00001584605,0.00007122679,0.00007742435,0.00004187787],"domain_scores_gemma":[0.9995054,0.0001117744,0.000198584,0.00006780052,0.00005485927,0.00006156399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1573732,0.006049548,0.04070451,0.0003871587,0.0003767707,0.001099957,0.0006130688,0.003054508,0.6631735,0.0001931229,0.0008828282,0.1260918],"study_design_scores_gemma":[0.006435791,0.4898845,0.3271101,0.00007176874,0.0003947748,0.003098798,0.0003340592,0.00608511,0.1626771,0.0002193496,0.003604351,0.0000842728],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981151,0.0006205642,0.0007399132,0.00002140645,0.000008542285,0.0000799535,0.00008921117,0.00003169255,0.0002936388],"genre_scores_gemma":[0.9984237,0.0002697225,0.0005309543,0.00006264286,0.00002592134,0.0000918067,0.000156355,0.000008852077,0.000429969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009074196,"threshold_uncertainty_score":0.003035605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1249008015970545,"score_gpt":0.4539404644745754,"score_spread":0.3290396628775209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}