{"id":"W2036318798","doi":"10.1200/edbook_am.2013.33.81","title":"Connecting Molecular Pathways to Hereditary Cancer Risk Syndromes","year":2013,"lang":"en","type":"review","venue":"American Society of Clinical Oncology Educational Book","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"SDHB; SDHD; BAP1; SDHA; Cancer research; Cancer; Fumarase; Paraganglioma; Germline mutation; Biology; Cowden syndrome; Cancer syndrome; Melanoma; Pathology; Medicine; Mutation; Genetics; Succinate dehydrogenase; Gene; Mitochondrion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226676,0.0007850208,0.0006809582,0.002278922,0.0003220236,0.0008179324,0.0006139813,0.0009324294,0.00601992],"category_scores_gemma":[0.0005919667,0.0002170836,0.0003159118,0.002308012,0.0005344967,0.001082942,0.0008147753,0.0014874,0.002710294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007713682,"about_ca_system_score_gemma":0.0008056095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148667,"about_ca_topic_score_gemma":0.001994446,"domain_scores_codex":[0.9998538,0.00002346338,0.00001781153,0.00002736682,0.00006067126,0.00001685985],"domain_scores_gemma":[0.999855,0.00006016331,0.00002296048,0.000005173452,0.0000411825,0.000015406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004601788,0.00005389731,0.000467899,0.01030086,0.00007572291,0.001780611,0.0001416532,0.0004247199,0.001890362,0.01361483,0.130996,0.8402076],"study_design_scores_gemma":[0.000009191697,0.00001759102,0.0007123558,0.002335773,0.00003827351,0.006702253,0.00005996135,0.0000506739,0.0002650162,0.003826382,0.9859698,0.00001266151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001533451,0.9945656,0.0002380052,0.0006998923,0.0004574392,0.000004703367,0.00002548899,0.00001780934,0.003837737],"genre_scores_gemma":[0.00103764,0.9956179,0.0003167263,0.0006255371,0.0004125727,0.000007977609,0.00005086713,0.000003451751,0.001927418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00601992,"threshold_uncertainty_score":0.02013862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.124149141516906,"score_gpt":0.4811537778855164,"score_spread":0.3570046363686105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}