{"id":"W2036338337","doi":"10.2217/nnm.14.123","title":"Development of Amino Acid Substituted Gemini Surfactant-Based Mucoadhesive Gene Delivery Systems for Potential use as Noninvasive Vaginal Genetic Vaccination","year":2015,"lang":"en","type":"article","venue":"Nanomedicine","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Pulmonary surfactant; Gene delivery; Vaginal delivery; Delivery system; Microbiology; Chemistry; Gene; Medicine; Biology; Genetic enhancement; Biochemistry; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009043187,0.0003895845,0.0006927286,0.00034428,0.0001955397,0.00001815978,0.0003206518,0.000396187,0.0001081593],"category_scores_gemma":[0.000308236,0.0003713445,0.0001032012,0.0003246095,0.0001467059,0.0002282945,0.00006237714,0.0003155252,0.00008352217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004710027,"about_ca_system_score_gemma":0.001106846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007796774,"about_ca_topic_score_gemma":0.00002292923,"domain_scores_codex":[0.9970238,0.0002879614,0.001070102,0.0005196874,0.0005280423,0.000570408],"domain_scores_gemma":[0.996734,0.0004649441,0.0006857907,0.0003095134,0.001354468,0.0004512388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004238952,0.0008056319,0.01037849,0.0007736409,0.0009313583,0.0005639661,0.003861156,0.03728803,0.9242218,0.0001221194,0.004044584,0.01277033],"study_design_scores_gemma":[0.02252471,0.001160409,0.007860865,0.000251981,0.0009311063,0.0003547147,0.002741511,0.04011628,0.8431353,0.00002630799,0.07987772,0.001019078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670151,0.003653749,0.02364304,0.0001145633,0.003412143,0.001793373,0.0001748957,0.00009448121,0.00009861966],"genre_scores_gemma":[0.9884504,0.0001547689,0.009573305,0.0002857152,0.0004392301,0.0002199989,0.0004080377,0.00005092957,0.0004175792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08108642,"threshold_uncertainty_score":0.9998739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285547716723133,"score_gpt":0.3869748777392866,"score_spread":0.2584201060669733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}