{"id":"W2036338337","doi":"10.2217/nnm.14.123","title":"Development of Amino Acid Substituted Gemini Surfactant-Based Mucoadhesive Gene Delivery Systems for Potential use as Noninvasive Vaginal Genetic Vaccination","year":2015,"lang":"en","type":"article","venue":"Nanomedicine","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Pulmonary surfactant; Gene delivery; Vaginal delivery; Delivery system; Microbiology; Chemistry; Gene; Medicine; Biology; Genetic enhancement; Biochemistry; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002821,0.0003276367,0.0001805065,0.0001996642,0.0001067767,0.0002551635,0.0002160652,0.0004639606,0.0003727354],"category_scores_gemma":[0.0002649164,0.0001199787,0.0001964097,0.0001331692,0.0001697118,0.0003829072,0.0001598881,0.0003804249,0.000201519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996875,"about_ca_system_score_gemma":0.0002304606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003252249,"about_ca_topic_score_gemma":0.0004723445,"domain_scores_codex":[0.9999094,0.00001814874,0.00001132459,0.00001721784,0.00003333356,0.00001048325],"domain_scores_gemma":[0.9998711,0.00002161045,0.00004579232,0.000008572236,0.00003405109,0.00001875179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002576487,0.00001315905,0.00008760612,0.00005315967,0.000003852942,0.00004500782,0.00001269585,0.0001041203,0.9960334,0.0001063661,0.00001572722,0.003499218],"study_design_scores_gemma":[0.00001288705,0.0002533513,0.0003410098,0.000005582982,0.00001373537,0.0001682377,0.00000730431,0.0009713753,0.9955615,0.00002370568,0.002637659,0.000003570342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9402455,0.01057525,0.04680408,0.0003529245,0.00007153861,0.0001989342,0.0001307536,0.0001891254,0.001431898],"genre_scores_gemma":[0.9391317,0.006216804,0.05169584,0.0001340822,0.00002467824,0.00009037121,0.0002837025,0.00003195042,0.00239089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004639606,"threshold_uncertainty_score":0.002174437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285547716723133,"score_gpt":0.3869748777392866,"score_spread":0.2584201060669733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}