{"id":"W2036352174","doi":"10.1073/pnas.1002036107","title":"Dynamic evolution of translation initiation mechanisms in prokaryotes","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Eukaryotic translation; Translation (biology); Genetics; Untranslated region; Ribosomal RNA; Shine-Dalgarno sequence; Five prime untranslated region; Coding region; Protein biosynthesis; Ribosome; Messenger RNA; Gene; RNA; Sequence (biology); Evolutionary biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009734186,0.00005357472,0.00007728802,0.0001055009,0.00004407608,0.000004363759,0.0002902554,0.0001166889,0.000005116396],"category_scores_gemma":[0.0002736973,0.00004026213,0.00004362858,0.0002716029,0.0001891719,0.00002621303,0.00003062474,0.00007030771,1.805361e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007669192,"about_ca_system_score_gemma":0.00003330641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004423703,"about_ca_topic_score_gemma":0.000001078647,"domain_scores_codex":[0.9991589,0.000006828563,0.0002311632,0.0001417324,0.0003890722,0.00007231644],"domain_scores_gemma":[0.9995495,0.00001988205,0.0002771748,0.000007509913,0.0001351756,0.00001074733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001508977,0.00002173364,0.0009153007,0.00002449741,0.000002812542,4.230346e-10,0.00003271451,0.00002726617,0.9531547,0.04514921,0.000002977414,0.0006536802],"study_design_scores_gemma":[0.00009699829,0.00005105797,0.02292949,0.000026594,0.000003289092,0.000001509703,0.00004235506,0.0007326054,0.8552037,0.1208643,0.00001001256,0.00003802605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979545,0.00007811205,0.000220531,0.0004464728,0.00002116791,0.0001831121,0.000007822021,0.000002071206,0.00108618],"genre_scores_gemma":[0.9925638,0.00001389365,0.007355926,0.00002031644,0.00001661131,0.00001072189,4.239238e-7,0.000002659478,0.00001561308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09795096,"threshold_uncertainty_score":0.1641842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950943731596596,"score_gpt":0.2772821782137597,"score_spread":0.2577727408977937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}