{"id":"W2036436704","doi":"10.1006/geno.2000.6282","title":"Succinyl-CoA:3-Ketoacid CoA Transferase (SCOT): Cloning of the Human SCOT Gene, Tertiary Structural Modeling of the Human SCOT Monomer, and Characterization of Three Pathogenic Mutations","year":2000,"lang":"en","type":"article","venue":"Genomics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Ministry of Education, Culture, Sports, Science and Technology; Ono Medical Research Foundation; Juvenile Diabetes Research Foundation United States of America","keywords":"Biology; Transferase; Missense mutation; Gene; Locus (genetics); Molecular biology; Exon; Homology (biology); Genetics; Biochemistry; Enzyme; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269255,0.0001473972,0.0001804705,0.00003101929,0.0001781525,0.00001329846,0.0003262634,0.0001466397,0.00001934381],"category_scores_gemma":[0.000009301155,0.0001085249,0.0001514647,0.00009748311,0.0002317244,0.00000653507,0.0001221962,0.0001418021,2.402485e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000133093,"about_ca_system_score_gemma":0.00007959059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009905545,"about_ca_topic_score_gemma":0.00007808327,"domain_scores_codex":[0.9989315,0.00006938529,0.0003863646,0.0002616839,0.0001531721,0.0001979544],"domain_scores_gemma":[0.9993221,0.000004673409,0.0001072129,0.0004223853,0.00009309381,0.00005050922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003132514,0.00002804007,0.003435676,0.00004930926,0.00005172391,2.898412e-7,0.0001485299,0.0007294224,0.994322,0.00005588197,0.000001158138,0.001146659],"study_design_scores_gemma":[0.000452842,0.00006140661,0.01664633,0.0000270476,0.00004760933,0.000007893333,0.00002014389,0.002161125,0.9801865,0.0002446195,0.00002486229,0.0001195733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983955,0.0004353696,0.0004755346,0.00006406991,0.00003148747,0.0003482851,0.0001994213,0.000003290563,0.00004705436],"genre_scores_gemma":[0.9992902,0.0001194409,0.0001680492,0.00005375153,0.00005137577,0.000008866056,0.0002461309,0.00002317301,0.00003903736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01413544,"threshold_uncertainty_score":0.4425515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237456743971893,"score_gpt":0.2399377913575893,"score_spread":0.2275632239178703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}