{"id":"W2036441002","doi":"10.1002/btpr.13","title":"Physicochemical characterization of siRNA‐peptide complexes","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Small interfering RNA; Circular dichroism; Dynamic light scattering; Chemistry; Biophysics; CTGF; Transfection; Zeta potential; Gene silencing; Peptide; RNA interference; RNA; Biochemistry; Nanoparticle; Materials science; Biology; Growth factor; Nanotechnology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004072554,0.000379369,0.0002299334,0.0004319462,0.0002731401,0.0003674007,0.0002382158,0.0002688725,0.001724162],"category_scores_gemma":[0.001112562,0.0001763855,0.0002282415,0.0003308018,0.0002738603,0.0002185617,0.0001652412,0.0004470966,0.0005280526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003714387,"about_ca_system_score_gemma":0.0002240279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007363205,"about_ca_topic_score_gemma":0.000452834,"domain_scores_codex":[0.9996539,0.00005375321,0.00003141053,0.000074173,0.0001457998,0.00004089033],"domain_scores_gemma":[0.9994987,0.0001750982,0.00008997816,0.00002201885,0.0001551548,0.00005901824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003537298,0.0000129499,0.0001689109,0.00003443247,0.000007434808,0.00007020313,0.00003623659,0.0001712083,0.9983381,0.00006195452,0.00003810034,0.001025173],"study_design_scores_gemma":[0.00001223134,0.0001618121,0.003397583,0.000006565949,0.00001326472,0.0002817704,0.00004386374,0.002180643,0.9917709,0.00007227081,0.002047746,0.00001148153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716396,0.002359689,0.01783974,0.0001417737,0.00005449062,0.0002805858,0.0008503307,0.0001355543,0.006698285],"genre_scores_gemma":[0.9821729,0.001097786,0.01025513,0.0001595133,0.00001894461,0.0003390571,0.001547352,0.00008081969,0.004328483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001724162,"threshold_uncertainty_score":0.005767882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424547776961249,"score_gpt":0.2420669099575685,"score_spread":0.2278214321879561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}