{"id":"W2036441002","doi":"10.1002/btpr.13","title":"Physicochemical characterization of siRNA‐peptide complexes","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Small interfering RNA; Circular dichroism; Dynamic light scattering; Chemistry; Biophysics; CTGF; Transfection; Zeta potential; Gene silencing; Peptide; RNA interference; RNA; Biochemistry; Nanoparticle; Materials science; Biology; Growth factor; Nanotechnology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002881836,0.0001102108,0.0001466278,0.00005301345,0.00004659076,0.0000029972,0.0002370319,0.000296867,0.000009555791],"category_scores_gemma":[0.00001580903,0.000105569,0.00006345898,0.00009528299,0.0005161524,0.000003430686,0.0001228511,0.00007540239,0.00001361518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000460135,"about_ca_system_score_gemma":0.00002732113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002893931,"about_ca_topic_score_gemma":0.000001055164,"domain_scores_codex":[0.9993382,0.00001500923,0.0001687942,0.0002415163,0.00007034032,0.0001661148],"domain_scores_gemma":[0.9994978,0.000002221493,0.000102141,0.000301961,0.00007106899,0.00002486157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004680992,0.00008730603,0.005317328,0.000009870857,0.00003309948,0.000003914879,0.00001551644,2.536894e-7,0.9912397,0.0001641724,0.0003575568,0.002724507],"study_design_scores_gemma":[0.0001974354,0.0002569523,0.006604416,0.00001205234,0.000006292367,0.00004482862,0.00001048616,0.00001443918,0.9857095,0.00002462779,0.007006955,0.0001119599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986767,0.0002678502,0.0004473497,0.0002858135,0.00006459919,0.0001070528,0.00002038547,0.00003834125,0.00009194588],"genre_scores_gemma":[0.9986498,0.0003209158,0.0004777739,0.00006794401,0.00008676144,0.00001741769,0.0001890404,0.00001158969,0.0001787005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006649398,"threshold_uncertainty_score":0.4304978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424547776961249,"score_gpt":0.2420669099575685,"score_spread":0.2278214321879561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}