{"id":"W2036441871","doi":"10.1016/j.jalz.2010.05.856","title":"P1‐303: Regulation of BACE1 and APP processing by Zinc signaling","year":2010,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Trace Elements in Health","field":"Nursing","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Senile plaques; Amyloid precursor protein; BACE1-AS; Gene expression; Molecular biology; Biology; Neurodegeneration; Alzheimer's disease; Signal transduction; Amyloid beta; Amyloid precursor protein secretase; Chemistry; Cell biology; Biochemistry; Transgene; Gene; Genetically modified mouse; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302895,0.0004340175,0.0003619927,0.0002581826,0.0003930844,0.0005108168,0.0003309427,0.0004823966,0.002622891],"category_scores_gemma":[0.0001655868,0.000167036,0.0003471912,0.0002578436,0.000244741,0.0003074894,0.0004024538,0.0005950567,0.001539477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000473295,"about_ca_system_score_gemma":0.000312809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052051,"about_ca_topic_score_gemma":0.0009731492,"domain_scores_codex":[0.9997802,0.00002547472,0.00001705988,0.00005791958,0.00006167201,0.00005766903],"domain_scores_gemma":[0.9999329,0.000008494686,0.00001543851,0.00000489946,0.0000158709,0.00002240785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403217,0.00004431085,0.0002267752,0.00008970281,0.000003945343,0.0002150853,0.00001553616,0.00003708055,0.9970114,0.0001817431,0.0001724454,0.001761603],"study_design_scores_gemma":[0.00004567447,0.0002096998,0.01029017,0.00001945171,0.00001533349,0.001121058,0.00007133275,0.001127925,0.9801205,0.0002465376,0.006718093,0.0000142456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683681,0.01177495,0.008119034,0.0007901705,0.0001882594,0.0001506641,0.002146713,0.0003716902,0.0080904],"genre_scores_gemma":[0.9772554,0.003892053,0.003148801,0.0002476192,0.00002916848,0.0001593629,0.002167183,0.00004834826,0.01305203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002622891,"threshold_uncertainty_score":0.008774459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812300656429566,"score_gpt":0.2913171820620932,"score_spread":0.2731941754977975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}