{"id":"W2036447740","doi":"10.1074/jbc.m110.216804","title":"Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sesquiterpenes and Asteraceae Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; Biotechnology and Biological Sciences Research Council","keywords":"Hydroxylation; Lactone; Sesquiterpene lactone; Biochemistry; Sesquiterpene; Cytochrome P450; Monooxygenase; Biology; Enzyme; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134101,0.0002624031,0.0004531623,0.00004020837,0.00007997816,0.00002717741,0.0001960339,0.0002399493,0.00006634741],"category_scores_gemma":[0.0003235423,0.0001941369,0.0001030535,0.00009517989,0.0001943166,0.00002144019,0.0002625052,0.0002699034,0.000001368899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001971009,"about_ca_system_score_gemma":0.00003517365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004740432,"about_ca_topic_score_gemma":0.00002230837,"domain_scores_codex":[0.9986871,0.00007655799,0.0004674925,0.0003837715,0.0001053225,0.0002797775],"domain_scores_gemma":[0.9991324,0.00009234749,0.0003155872,0.0001711558,0.0001332125,0.0001552747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000701813,0.0002518744,0.04369036,0.00002283448,0.0002145094,0.0001553318,0.0003085711,0.000001050832,0.9533212,0.000007407707,0.00009989768,0.001225173],"study_design_scores_gemma":[0.00176436,0.00034411,0.296775,0.0000994487,0.0001074324,0.0004828462,0.0004499909,0.00001784996,0.6967928,0.0003718914,0.002350384,0.0004438924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897278,0.009286792,0.00005914757,0.0001362602,0.00007470247,0.00009675696,0.00008767663,0.00000587297,0.0005250047],"genre_scores_gemma":[0.9978825,0.001239994,0.0003061152,0.0001370611,0.0002879321,0.000008049432,0.00004239196,0.00001420571,0.00008175342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2565284,"threshold_uncertainty_score":0.7916671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814004032333256,"score_gpt":0.2518835976897547,"score_spread":0.2237435573664221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}