{"id":"W2036447740","doi":"10.1074/jbc.m110.216804","title":"Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sesquiterpenes and Asteraceae Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; Biotechnology and Biological Sciences Research Council","keywords":"Hydroxylation; Lactone; Sesquiterpene lactone; Biochemistry; Sesquiterpene; Cytochrome P450; Monooxygenase; Biology; Enzyme; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007018885,0.0003627593,0.000237162,0.000273647,0.0001850628,0.0002442466,0.00009742195,0.000244892,0.0008588879],"category_scores_gemma":[0.00009953213,0.000129531,0.0003525499,0.0001880081,0.0001132921,0.0001400452,0.0001434696,0.0003217754,0.0005422726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212588,"about_ca_system_score_gemma":0.0001837383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001627201,"about_ca_topic_score_gemma":0.001752434,"domain_scores_codex":[0.9999237,0.000006102808,0.000006509776,0.00002668777,0.00001656003,0.00002033883],"domain_scores_gemma":[0.9999185,0.00001316178,0.00002453988,0.000008190314,0.00001459907,0.00002103424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009854233,0.00001757046,0.001373257,0.00001986113,0.00000614859,0.0000764342,0.00002216595,0.00003178243,0.9956863,0.00003858421,0.00005311268,0.002576268],"study_design_scores_gemma":[0.00003394823,0.0002996731,0.09673882,0.00000667659,0.00004355697,0.001683602,0.00008023412,0.0008351192,0.8950611,0.0001043813,0.005099926,0.00001296741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917532,0.001746729,0.003837754,0.0001266549,0.00002731087,0.00002799156,0.001106203,0.0001442315,0.001229918],"genre_scores_gemma":[0.985989,0.0007517898,0.002485735,0.00009210291,0.00002341484,0.00003212076,0.005791428,0.0000335789,0.00480077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001627201,"threshold_uncertainty_score":0.003235459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814004032333256,"score_gpt":0.2518835976897547,"score_spread":0.2237435573664221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}